ArticleJCO oncology practice2021
Functional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.
Article in JCO oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Recommendations for Interventions to Improve Function in Patients With Lung Cancer: A Clinical Practice Guideline.Cancer medicine · 2025Guideline
- Resiliency among older adults receiving lung cancer treatment (ROAR-LCT): A novel supportive care intervention for older adults with advanced lung cancer.Journal of geriatric oncology · 2024Trial
- Trial
- Using Patient-Reported Outcome Measures to Identify Mobility Limitation in Incurable Cancer.Archives of rehabilitation research and clinical translation · 2026Article
- Pulmonary Arterial Hypertension and Cancer: Unveiling Parallels in Epidemiology, Clinical Pathways, and Therapeutic Strategies.Journal of market access & health policy · 2026Article
- The Fifth Annual Symposium of the Midwest Aging Consortium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Disability and long-term breathlessness: a cross-sectional, population study.BMJ open respiratory research · 2024Article
- Article
- Estimation of disability free life expectancy in non small cell lung cancer based on real world data.Scientific reports · 2023Article
- Risk Factors for Immune Checkpoint Inhibitor Immunotherapy Toxicity Among Older Adults with Cancer.The oncologist · 2023Article
- Illness perception profiles and psychological and physical symptoms in newly diagnosed advanced non-small cell lung cancer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- "You have to be sure that the patient has the full picture": Adaptation of the Best Case/Worst Case communication tool for geriatric oncology.Journal of geriatric oncology · 2022Article
- Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer.JTO clinical and research reports · 2022Article
- Radiotherapy-Related Fatigue Associated Impairments in Lung Cancer Survivors during COVID-19 Voluntary Isolation.Healthcare (Basel, Switzerland) · 2022Article
- A Geriatric Assessment Intervention to Reduce Treatment Toxicity Among Older Adults With Advanced Lung Cancer: A Subgroup Analysis From a Cluster Randomized Controlled Trial.Frontiers in oncology · 2022Article
- Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study.Journal of the American Geriatrics Society · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).
methodsIn a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Patients were classified into two disability groups (none-slight or moderate-severe) on the basis of total functional status scores. Differences between disability groups were determined (chi-square and
resultsAmong 173 participants, mean age was 63.3 years, 56% were male, 83% had ECOG PS 0-1, and 41% had brain metastases. Baseline disability was present in 39% of participants, with patients having moderate to severe disability in usual activities (37.6%), mobility (26.6%), and self-care (5.2%). Depressive and/or anxiety symptoms ranged from none to severe (Patient Health Questionnaire 9-item scale M = 6.5, SD = 5.3). Depressive symptoms were the only characteristic associated with a higher odds of baseline disability (adjusted odds ratio [aOR]: 1.26; 95% CI, 1.15 to 1.38;
conclusionMore than one third of all adults with advanced NSCLC have moderate-severe functional disability at baseline. Psychologic symptoms were significantly associated with moderate-severe baseline disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.