Observational studyJournal of cachexia, sarcopenia and muscle2021
Prognostic impact of muscle and fat mass in patients with heart failure.
Observational study in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Exploring the Impact of Selenium Supplementation on Nutritional, Inflammatory, and Cardiac Function in Chronic Heart Failure Patients: A Novel Approach to Managing Deficiency.Cardiovascular toxicology · 2025Pooled it
- Are sarcopenia and its individual components linked to all-cause mortality in heart failure? A systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Pooled it
- Comparison of sarcopenia prevalence and prognostic features between HFrEF and HFpEF: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- High-intensity interval training versus moderate-intensity continuous training in patients with heart failure: a systematic review and meta-analysis.Heart failure reviews · 2023Pooled it
- Sex- and phenotype-specific prognostic implications of body mass index in acute heart failure.ESC heart failure · 2026Article
- Risk factors analysis of right ventricular-arterial uncoupling in patients having acute heart failure with preserved ejection fraction accompanied by coronary artery disease.BMC cardiovascular disorders · 2026Article
- Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.Journal of cachexia, sarcopenia and muscle · 2026Article
- Low muscle, high leak? The aMFR wake-up call for women's bladders!BJUI compass · 2026Article
- The Relationship between Sarcopenia and All-Cause and Cardiovascular Mortality Risk among Middle-Aged and Older Adults across Stages 0-3 of Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES and CHARLS.Cardiorenal medicine · 2026Article
- Body composition phenotypes and phase angle as predictors of mortality in subjects with right ventricular dysfunction: a prospective cohort study.Frontiers in nutrition · 2026Article
- Impact of lean body mass index on short-term outcomes in patients with ischemic stroke: an observational cohort study.Scientific reports · 2025Observational
- Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- The influence of muscle size and density, as well as subcutaneous adipose tissue, on mortality risk in elderly women across different age groups.BMC musculoskeletal disorders · 2025Article
- The size and density of muscle and subcutaneous adipose tissue are independently associated with the risk of mortality in older women with different hip fracture types.Journal of orthopaedic surgery and research · 2025Article
- Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).Age and ageing · 2025Article
- Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure-A prospective cohort study.ESC heart failure · 2025Article
- The new definition of metabolic syndrome including hyperuricemia improves its prognostic value: results from NHANES database.BMC cardiovascular disorders · 2025Article
- Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria-A Long-Term CMR Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Prognostic implication of sarcopenia diagnosed by updated Asian Working Group for Sarcopenia criteria in older patients with heart failure: Utility and limitation.The journal of nutrition, health & aging · 2025Article
- Associations between in-hospital daily protein intake and adverse clinical outcomes in older patients with heart failure.ESC heart failure · 2024Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCachexia, characterized by loss of muscle with or without loss of fat mass, is a poor prognostic factor in patients with heart failure (HF). However, there is limited investigation on the prognostic impact of muscle and fat mass separately in HF. We hypothesized that muscle and fat mass have different effects on the prognosis of HF.
methodsThis was an observational cohort study of 418 patients (59% were men) admitted with a diagnosis of HF (71 ± 13 years [mean ± standard deviation]), with left ventricular ejection fraction (LVEF) of 39 ± 16%, including 31.3%, 14.8%, and 53.8% of patients with preserved LVEF (LVEF ≥ 50%), mid-range LVEF (40-50%), and reduced (<40%) LVEF, respectively. Dual-energy X-ray absorptiometry was performed with the patients in the stable state after decongestion therapy.
resultsThe mean body mass index of patients was 22.1 ± 4.6 kg/m
conclusionsMore than half of the patients with HF showed reduced muscle mass. Lower values of both muscle and fat mass were associated with higher mortality in HF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.