Evidence map›Paper›PMID 33939300›Full record

ArticleESC heart failure2021

Visceral adiposity, muscle composition, and exercise tolerance in heart failure with preserved ejection fraction.

Wendy Ying, Kavita Sharma, Lisa R Yanek, Dhananjay Vaidya, Michael Schär, Michael Markl, Vinita Subramanya, Sahar Soleimani, Pamela Ouyang, Erin D Michos and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Epicardial Adipose Tissue in Duchenne Muscular Dystrophy Cardiomyopathy.Journal of the American Heart Association · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Epicardial adipose tissue and exercise intolerance in HFpEF.International journal of cardiology. Heart & vasculature · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Wendy YingSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.ORCID 0000-0002-7862-5508
Kavita SharmaSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Lisa R YanekSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Dhananjay VaidyaSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Michael SchärSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Michael MarklFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Vinita SubramanyaRollins School of Public Health, Emory University, Atlanta, GA, USA.
Sahar SoleimaniSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Pamela OuyangSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Erin D MichosSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.
Sanjiv J ShahFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Allison G HaysSchool of Medicine, Johns Hopkins University, 600 N. Wolfe St., Baltimore, MD, 21287, USA.ORCID 0000-0003-2138-1589
Johns Hopkins University · USNorthwestern University · USEmory University · US

Funding

Emerging factors in the pathophysiology of endothelial dysfunction in HIV+ womenR01HL147660 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HAYS, ALLISON G · 2019 to 2023
$1.4M
NHLBI NIH HHS R01 HL147660
6 · The paper itself

Abstract

aimsVisceral adipose tissue (AT) promotes inflammation and may be associated with disease progression in heart failure with preserved ejection fraction (HFpEF). We characterized regional AT distribution in HFpEF patients and controls and analysed associations with co-morbidities and exercise tolerance. METHODS AND

resultsMagnetic resonance imaging was performed to quantify epicardial, liver, abdominal, and thigh skeletal muscle AT. We assessed New York Heart Association (NYHA) class, 6 min walk distance, and global well-being score. Multivariable linear regression models adjusting for body surface area were used. We studied 55 HFpEF patients (41 women, mean age 67 ± 11 years) and 33 controls (21 women, mean age 57 ± 10 years). Epicardial AT (median [interquartile range] 4.6 [2.0] vs. 3.2 [1.4] mm, P < 0.001), thigh intermuscular fat (11.0 [11.5] vs. 5.0 [2.7] cm

conclusionsHeart failure with preserved ejection fraction patients have increased epicardial, liver, and skeletal muscle fat compared with controls out of proportion to their increased body size, and adiposity was associated with worse NYHA class and exercise tolerance in HFpEF. These results provide the basis for further investigation into the effect of interventions to reduce regional AT distribution in relation to HFpEF symptoms and pathophysiology.

Indexed as

Exercise ToleranceHeart FailureAdiposityAgedFemaleHumansMaleMiddle AgedMuscle, SkeletalStroke VolumeAdipose tissueExercise toleranceHeart failure with preserved ejection fractionMagnetic resonance imagingObesityRisk factors

Identifiers

PMID33939300
PMCPMC8318398
OpenAlexW3158231033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.