ArticleESC heart failure2021
The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04064450 (MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MyoVasc - An Epidemiological Cohort Study to Investigate the Development and Progression of Heart Failure and the Interaction With Vascular Disease
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The impact of platelet-to-lymphocyte ratio on clinical outcomes in heart failure: a systematic review and meta-analysis.Therapeutic advances in cardiovascular diseasePooled it
- Longitudinal Endothelial Activation and Stress Index (EASIX) trajectories and mortality risk in chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Inflammatory Biomarkers and Their Associations with Arrhythmic Burden Following SGLT2-I Treatment in Chronic Heart Failure-A Subanalysis of the ERASe Trial.Journal of clinical medicine · 2026Article
- Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction.ESC heart failure · 2025Article
- Exploring the Platelet-to-Lymphocyte Ratio for Risk Stratification in Heart Failure: A Systematic Review.Cureus · 2025Review
- Application of Hybrid Platelet Technology for Platelet Count Improves Accuracy of PLT Measurement in Samples from Patients with Different Types of Anemia.Journal of clinical medicine · 2025Article
- Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study.Cardiovascular diabetology · 2025Article
- Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities.ESC heart failure · 2025Review
- Article
- Association between the platelet-albumin-bilirubin score and all-cause mortality in ICU-admitted heart failure patients: a retrospective cohort analysis and machine learning-based prognostic modeling.Frontiers in cardiovascular medicine · 2025Article
- Systemic Inflammatory Response Index Is a More Promising Prognostic Index Than Systemic Immune Inflammation Index in Critically Ill Heart Failure Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.Vascular health and risk management · 2025Article
- Prognostic value of platelet volume indices in heart failure: a systematic review and meta-analysis.American journal of blood research · 2025Review
- Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from Jiangxi, China.Frontiers in cardiovascular medicine · 2025Article
- Article
- Association of platelet-to-lymphocyte ratio with 1-year all-cause mortality in ICU patients with heart failure.Scientific reports · 2024Article
- First- vs. Second-Generation Autologous Platelet Concentrates and Their Implications for Wound Healing: Differences in Proteome and Secretome.Bioengineering (Basel, Switzerland) · 2024Article
- Incidence and predictors of unplanned 30-day hospital readmissions among heart failure patients in Ethiopia: a 5-year retrospective cohort study.Scientific reports · 2024Article
- The potential of platelet to high-density lipoprotein cholesterol ratio (PHR) as a novel biomarker for heart failure.Scientific reports · 2024Article
- Platelet count in heart failure patients undergoing left ventricular assist device.ESC heart failure · 2024Article
- Associations between static and dynamic changes of platelet counts and in-hospital mortality in critical patients with acute heart failure.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsPlatelet indices have been associated with traditional cardiovascular risk factors, cardiovascular diseases and all-cause mortality. This study aimed to investigate the role of platelet count, mean platelet volume (MPV) and platelet-to-leukocyte ratio, including platelet-to-monocyte and platelet-to-lymphocyte ratio with cardiac function, heart failure (HF) phenotypes and clinical outcome, worsening of HF. METHODS AND
resultsUnivariate and multivariable linear and Cox regression analyses were used to investigate the associations between platelet indices, cardiac function and worsening of HF in 3250 subjects enrolled in the MyoVasc study. Higher MPV, lower platelet count, lower platelet-to-leukocyte and platelet-to-monocyte ratios have been associated with reduced left ventricular ejection fraction (beta estimate [β]
conclusionsPlatelet indices are linked with worse cardiac function and adverse clinical outcome, independent of subjects' underlying cardiovascular profile. This study emphasizes their important value to provide additional information on pathophysiology and risk stratification in HF syndrome.
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