Evidence map›Paper›PMID 33938954›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

The effect of codeine administration on oxidative stress biomarkers and the expression of the neuron-specific enolase in the brain of Wistar rats.

Victor Bassey Archibong, Theresa Ekanem, Anozeng Igiri, Emmanuel Oleba Ofutet, Josiah Eseoghene Ifie

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Victor Bassey ArchibongDepartment of Human Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Ishaka, Uganda.
Theresa EkanemDepartment of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.
Anozeng IgiriDepartment of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria.
Emmanuel Oleba OfutetDepartment of Physiology, College of Medical Sciences, University of Calabar, Cross River State, Calabar, Nigeria.
Josiah Eseoghene IfieDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Ishaka, Uganda. ifiejosiah.ese@kiu.ac.ug.ORCID http://orcid.org/0000-0002-2714-3322
University of Calabar · NGKampala International University · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to assess the effects of codeine medication on some oxidative stress parameters and how it affects the expression of enolase in neuronal cells. The codeine medication used for the study was Archilin™ with codeine syrup and dihydrocodeine 30 mg. The study used 30 male Wistar rats which were grouped in five: A, B, C, D, and E (n = 6), while treatments were administered for 21 days. Based on the LD

Indexed as

Analgesics, OpioidAnimalsBiomarkersBrainCodeineDose-Response Relationship, DrugGlucoseMaleMalondialdehydeOxidative StressPhosphopyruvate HydrataseRatsRats, WistarSuperoxide DismutaseAnalgesics, OpioidBiomarkersCodeinedihydrocodeineGlucoseMalondialdehydePhosphopyruvate HydrataseSuperoxide DismutaseCodeineDrug abuseNeuron-specific enolaseOpioidsOxidative stress

Identifiers

PMID33938954
OpenAlexW3157377440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.