Evidence map›Paper›PMID 33938724›Full record

ReviewChemical reviews2021

Translational Applications of Hydrogels.

Santiago Correa, Abigail K Grosskopf, Hector Lopez Hernandez, Doreen Chan, Anthony C Yu, Lyndsay M Stapleton, Eric A Appel

Open access · hybridAbstract readReview
In one paragraph

Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 341 papers.

0numbers the graph read from it
0cells of the map it votes in
341citing papers in PubMed
55.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

341 citing papers in PubMed, 1,015 citations in OpenAlex.

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  18. Hydraulic Pressure-Programmed Molecular Transport in Tough Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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281 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Santiago CorreaMaterials Science & Engineering, Stanford University, Stanford, California 94305, United States.
Abigail K GrosskopfChemical Engineering, Stanford University, Stanford, California 94305, United States.
Hector Lopez HernandezMaterials Science & Engineering, Stanford University, Stanford, California 94305, United States.
Doreen ChanChemistry, Stanford University, Stanford, California 94305, United States.
Anthony C YuMaterials Science & Engineering, Stanford University, Stanford, California 94305, United States.
Lyndsay M StapletonBioengineering, Stanford University, Stanford, California 94305, United States.
Eric A AppelMaterials Science & Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-2301-7126
Stanford University · USPalo Alto Institute · US

Funding

An injectable hydrogel platform for sustained release of eCD4-IgR01AI154989 · NIAID · UNIVERSITY OF FLORIDA · PI APPEL, ERIC ANDREW, FARZAN, MICHAEL R. · 2020 to 2024
$4.2M
Cancer immunotherapy using injectable hydrogels for precise and tunable multidrug deliveryF32CA247352 · NCI · STANFORD UNIVERSITY · PI CORREA, SANTIAGO · 2020 to 2022
$201k
NCI NIH HHS F32 CA247352NIAID NIH HHS R01 AI154989
6 · The paper itself

Abstract

Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant to a range of biomedical purposes-they can deliver drugs or cells, regenerate hard and soft tissues, adhere to wet tissues, prevent bleeding, provide contrast during imaging, protect tissues or organs during radiotherapy, and improve the biocompatibility of medical implants. These capabilities make hydrogels useful for many distinct and pressing diseases and medical conditions and even for less conventional areas such as environmental engineering. In this review, we cover the major capabilities of hydrogels, with a focus on the novel benefits of injectable hydrogels, and how they relate to translational applications in medicine and the environment. We pay close attention to how the development of contemporary hydrogels requires extensive interdisciplinary collaboration to accomplish highly specific and complex biological tasks that range from cancer immunotherapy to tissue engineering to vaccination. We complement our discussion of preclinical and clinical development of hydrogels with mechanical design considerations needed for scaling injectable hydrogel technologies for clinical application. We anticipate that readers will gain a more complete picture of the expansive possibilities for hydrogels to make practical and impactful differences across numerous fields and biomedical applications.

Indexed as

HydrogelsTissue EngineeringProstheses and ImplantsHydrogels

Identifiers

PMID33938724
PMCPMC8461619
OpenAlexW3157057024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.