ArticleJournal of veterinary internal medicine2021
Risk factors for laminitis and nonsurvival in acute colitis: Retrospective study of 85 hospitalized horses (2011-2019).
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Clinical predictive models in equine medicine: A systematic review.Equine veterinary journal · 2023Pooled it
- A novel kirkovirus may be associated with equine gastrointestinal disease.Equine veterinary journal · 2026Article
- A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis.Veterinary sciences · 2024Review
- Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study.PloS one · 2024Article
- Association of the type of metabolic acidosis and non-survival of horses with colitis.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Relationship between the Cycle Threshold Value (Ct) of aMicroorganisms · 2023Article
- Postmortem examination of equids >1-year-old with enterotyphlocolitis in Ontario: a retrospective descriptive study.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Review
- Prognostic indicators for survival of downer cattle treated using a flotation tank in a referral hospital: 190 cases (2000-2020).Journal of veterinary internal medicine · 2023Article
- Fecal microbiota of horses with colitis and its association with laminitis and survival during hospitalization.Journal of veterinary internal medicine · 2022Article
- Acute diarrhea in horses: A multicenter Canadian retrospective study (2015 to 2019).The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Effect of season and geographic location in the United States on detection of potential enteric pathogens or toxin genes in horses ≥6-mo-old.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Risk factors for laminitis and nonsurvival in acute colitis: Retrospective study of 85 hospitalized horses (2011-2019).Journal of veterinary internal medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute colitis is a serious cause of morbidity and death in horses. Recent studies have compared clinical features of coronavirus and salmonellosis, but no study has compared clinical features of enteric salmonellosis, coronavirus, and neorickettsiosis. HYPOTHESIS/
objectivesTo identify risk factors for laminitis and nonsurvival to discharge in horses with enteric salmonellosis, coronavirus, or neorickettsiosis. ANIMALS: Eighty-five horses hospitalized for acute colitis from 2011 to 2019.
methodsRetrospective case series. Medical record review (2011-2019) of adult (≥2 years) horses with colitis. Primary outcomes were laminitis and survival to discharge. Multivariable logistic regression was performed to assess association between variables and the development of laminitis. Stepwise Cox regression was performed to assess association between variables and survival.
resultsSeventeen of 85 (20%) horses developed laminitis during hospitalization. Neorickettsiosis cases (11/26, 42%) were more likely to develop laminitis than coronavirus (0/16, 0%) cases (odds ratio [OR] 24.48; 95% confidence interval [CI]: 1.33-451.74, P = .03). There was no significant difference in laminitis between salmonellosis and neorickettsiosis cases (OR 0.27; 95% CI: 0.07-1.07, P = .06). Admission heart rate (OR 1.08; 95% CI: 1.02-1.15, P = .01), total solids (OR 0.17; 95% CI: 0.06-0.54, P = .003), band neutrophils (OR 1248.47; 95% CI: 6.62-235 540, P = .008), and bicarbonate concentration (OR 0.68; 95% CI: 0.5-0.92, P = .01) were predictive of development of laminitis during hospitalization. Sixty-three of 85 (74%) horses survived to discharge: 16/16 (100%) coronavirus cases, 17/26 (65%) neorickettsiosis cases, 14/20 (70%) salmonellosis cases, and 16/23 (70%) unknown cases. Packed cell volume (hazard ratio [HR] 1.17; 95% CI: 1.09-1.26, P < .001), L-lactate concentration (HR 1.33; 95% CI: 1.14-1.55, P < .001), and development of laminitis (HR 7.07; 95% CI: 1.67-29.95, P = .008) were retained in the final multivariable model for prediction of nonsurvival to discharge. CONCLUSION AND CLINICAL IMPORTANCE: Nonsurvival and laminitis rates were high, likely related to the presence of neorickettsiosis in the region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.