Evidence map›Paper›PMID 33938239›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Deletion of

R B Thomson, D W Dynia, S Burlein, B R Thomson, C J Booth, F Knauf, T Wang, P S Aronson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. CaAntibodies (Basel, Switzerland) · 2026
    Article
  2. Lineage tracing reveals KSPFrontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

R B ThomsonDepartment of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut.
D W DyniaDepartment of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut.
S BurleinDepartment of Nephrology and Hypertension, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
B R ThomsonFeinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
C J BoothDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut.
F KnaufDepartment of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
T WangDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut.
P S AronsonDepartment of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-1860-2419
Yale University · USCharité - Universitätsmedizin Berlin · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DENorthwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
The Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI CAPLAN, MICHAEL J. · 1986 to 2018
$29.5M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8M
Therapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L., QUAGGIN, SUSAN E. · 2018 to 2022
$5.7M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P01DK017433HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK114857NCI NIH HHS P30 CA060553NIDDK NIH HHS P01 DK017433NIDDK NIH HHS P30 DK079310NIDDK NIH HHS P30 DK114857
6 · The paper itself

Abstract

Ksp-cadherin (cadherin-16) is an atypical member of the cadherin superfamily of cell adhesion molecules that is ubiquitously expressed on the basolateral membrane of epithelial cells lining the nephron and the collecting system of the mammalian kidney. The principal aim of the present study was to determine if Ksp-cadherin played a critical role in the development and maintenance of the adult mammalian kidney by generating and evaluating a mouse line deficient in Ksp-cadherin. Ksp-null mutant animals were viable and fertile, and kidneys from both neonates and adults showed no evidence of structural abnormalities. Immunolocalization and Western blot analyses of Na

Indexed as

AnimalsAquaporin 2CadherinsGene Expression Regulation, DevelopmentalKidneyKidney Concentrating AbilityMaleMiceMice, KnockoutSodium-Potassium-Exchanging ATPaseAqp2 protein, mouseAquaporin 2CadherinsCdh16 protein, mouseCdh1 protein, mouseSodium-Potassium-Exchanging ATPasecadherinkidney developmenturinary concentrating ability

Identifiers

PMID33938239
PMCPMC8285649
OpenAlexW3157489724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.