ArticleJournal of the American Heart Association2021
Adverse Childhood Experiences and the Risk of Coronary Heart Disease in Adulthood: Examining Potential Psychological, Biological, and Behavioral Mediators in the Whitehall II Cohort Study.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood experiences.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.Behavioral sciences (Basel, Switzerland) · 2026Review
- Emerging Perspectives on Adverse Childhood Experiences and Brain Cancer Immunotherapy.Cancers · 2026Article
- Adverse childhood experiences and hypertension jointly increase cardiovascular risk: evidence from three national aging cohorts.BMC public health · 2026Article
- Rats exposed to a low resource environment in early life display sex differences in blood pressure, autonomic activity, and brain and kidney pro-inflammatory markers during adulthood.Biology of sex differences · 2026Article
- Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study.BMJ public health · 2026Article
- Rats Exposed to a Low Resource Environment in Early Life Display Sex Differences in Blood Pressure, Autonomic Activity, and Brain and Kidney Pro-inflammatory Markers During Adulthood.Research square · 2025Article
- Rats Exposed to a Low Resource Environment in Early Life Display Sex Differences in Blood Pressure, Autonomic Activity, and Brain and Kidney Pro-inflammatory Markers During Adulthood.bioRxiv : the preprint server for biology · 2025Article
- Positive childhood experiences and adult cardiovascular health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Parental imprisonment, childhood behavioral problems, and adolescent and young adult cardiometabolic risk: results from a prospective Australian birth cohort study.Health & justice · 2025Article
- Adverse childhood experiences and arthritis risk: exploring behavioral and psychological mediators in the behavioral risk factor surveillance system.Frontiers in public health · 2025Article
- The mediating effect of depressive syndrome on the relationship between adverse childhood experiences and chronic kidney diseases among middle-aged and older adults.Frontiers in public health · 2025Article
- Adverse childhood experiences and hypertension: examining the roles of depressive symptoms and cardiometabolic dysregulations based on CHARLS data.Frontiers in public health · 2025Article
- Uncovering psychologically mediated pathways to cardiovascular diseases: depressive symptoms as a mediator between childhood maltreatment and single or multiple cardiovascular disease comorbidities.Frontiers in psychiatry · 2025Article
- Childhood Exposure to Interparental Physical Violence and Adult Cardiovascular Disease.JAMA network open · 2024Article
- Adverse childhood experiences and adult disease: Examining mediating pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Allostasis, health, and development in Latin America.Neuroscience and biobehavioral reviews · 2024Review
- Adversities in childhood and young adulthood and incident cardiovascular diseases: a prospective cohort study.EClinicalMedicine · 2024Article
- Exposure to Adversity and its Impact on Later Life Cognitive, Mental, and Physical Health.International journal of public health · 2024Article
- Association between adverse childhood experiences and fruit and vegetable intake among a national sample of U.S. adults.Preventive medicine reports · 2023Article
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Abstract
Background This study investigated potential psycho-bio-behavioral mediators of the association between adverse childhood experiences (ACEs) and the risk of coronary heart disease (CHD) in adulthood. Methods and Results Participants were 5610 British civil servants (mean age, 55.5; 28% women) from the Whitehall II cohort study without CHD at baseline in 1997 to 1999 (wave 5) when retrospective data on the number of ACEs were collected via questionnaire (range, 0-8). Potential mediators assessed at wave 5 included depression and anxiety symptoms, health behaviors (smoking, alcohol dependence, sleep, and physical activity), and cardiometabolic dysregulations. New diagnoses of CHD (myocardial infarction, definite angina, coronary artery bypass grafting, or percutaneous transluminal coronary angioplasty) were assessed from wave 6 (2001) to wave 11 (2012-2013). Logistic regressions examined associations between ACEs, potential mediators, and CHD during the follow-up period. Natural indirect effects were examined using mediation analysis. A total of 566 (10.1%) participants developed CHD during the follow-up period. ACEs were associated with an increased likelihood of CHD (odds ratio per ACE, 1.09; 95% CI, 1.00-1.19). Controlling for age and sex, mediation analyses revealed an indirect effect of depression symptoms (natural indirect effects, 1.05; 95% CI, 1.03-1.07), anxiety symptoms (natural indirect effects, 1.12; 95% CI, 1.10-1.15), and a greater number of cardiometabolic dysregulations (natural indirect effects, 1.02; 95% CI, 1.01-1.03) in the association between ACEs and incident CHD. Behavioral factors were not statistically significant mediators. Conclusions Depression symptoms, anxiety symptoms, and cardiometabolic dysregulations partially mediated the association between ACEs and CHD. Regular screening and treatment of symptoms of psychological disorders and cardiometabolic dysregulations may help mitigate the long-term health burden of ACEs.
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