Evidence map›Paper›PMID 33937952›Full record

ArticleLasers in medical science2022

Efficacy of 5-aminolevulinic acid-based photodynamic therapy in different subtypes of canine mammary gland cancer cells.

Ozge Turna, Aslihan Baykal, Elif Sozen Kucukkara, Ozge Ozten, Asuman Deveci Ozkan, Gamze Guney Eskiler, Ali Furkan Kamanli, Cemil Bilir, Salih Zeki Yildiz, Suleyman Kaleli and 3 more

Abstract read
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In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ozge TurnaDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul-Cerrahpasa University, Istanbul, Turkey.
Aslihan BaykalDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul-Cerrahpasa University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-2107-1874
Elif Sozen KucukkaraDepartment of Medical Biochemistry, Institute of Health Sciences, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-4246-7333
Ozge OztenDepartment of Biomedical Engineering, Institute of Graduate Education, Sakarya University of Applied Science, Sakarya, Turkey.
Asuman Deveci OzkanDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Korucuk Campus, 54290, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-3248-4279
Gamze Guney EskilerDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Korucuk Campus, 54290, Sakarya, Turkey. gamzeguney@sakarya.edu.tr.ORCID http://orcid.org/0000-0002-2088-9914
Ali Furkan KamanliDepartment of Electric and Electronics Engineering, Technology Faculty, Sakarya University of Applied Sciences, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-4155-5956
Cemil BilirDepartment of Medical Oncology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-1372-4791
Salih Zeki YildizDepartment of Chemistry, Faculty of Arts and Sciences, Sakarya University, Sakarya, Turkey.ORCID https://orcid.org/0000-0001-5086-8770
Suleyman KaleliDepartment of Medical Biology, Faculty of Medicine, Sakarya University, Korucuk Campus, 54290, Sakarya, Turkey.ORCID https://orcid.org/0000-0002-6043-2521
Melih UcmakDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul-Cerrahpasa University, Istanbul, Turkey.
Guven KasikciDepartment of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul-Cerrahpasa University, Istanbul, Turkey.
Hyun Soo LimDepartment of Electric and Electronics Engineering, Technology Faculty, Sakarya University of Applied Sciences, Sakarya, Turkey.
Sakarya University · TRIstanbul University-Cerrahpaşa · TR

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu 119O383
6 · The paper itself

Abstract

Canine mammary gland tumors (CMGTs) are heterogeneous disease and subclassified [sarcomas (S), carcinomas (C), and carcinosarcomas (CS)] according to histopathological differentiation. Photodynamic therapy (PDT) is a promising treatment strategy based on the use of a photosensitizer (PS) activated by light. However, the therapeutic potential of PDT in the treatment of CMGTs has not been investigated, yet. Therefore, the aim of this study was to determine the in vitro protocol of 5-ALA-based-PDT for the treatment of three subtypes of CMGTs, for the first time. The intracellular PpIX florescence intensity was measured for 5-ALA (0.5 and 1 mM). After irradiation with different light doses (6, 9, 12, 18, and 24 J/cm

Indexed as

NeoplasmsPhotochemotherapyAminolevulinic AcidAnimalsApoptosisCell Line, TumorDogsPhotosensitizing AgentsProtoporphyrinsAminolevulinic AcidPhotosensitizing AgentsProtoporphyrins5-Aminolevulinic acidApoptosisCanine mammary gland tumorPhotodynamic therapy

Identifiers

PMID33937952
OpenAlexW3159718268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.