Evidence map›Paper›PMID 33937911›Full record

ArticleNeurotrauma reports2021

Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.

Frederick K Korley, Saul A Datwyler, Sonia Jain, Xiaoying Sun, Gangamani Beligere, Raj Chandran, Jaime A Marino, Beth McQuiston, Hongwei Zhang, Krista L Caudle and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
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  3. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Frederick K KorleyDepartment of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Saul A DatwylerAbbott Laboratories, Abbott Park, Illinois, USA.
Sonia JainHerbert Wertheim School of Public Health, University of California, San Diego, La Jolla, California, USA.
Xiaoying SunHerbert Wertheim School of Public Health, University of California, San Diego, La Jolla, California, USA.
Gangamani BeligereAbbott Laboratories, Abbott Park, Illinois, USA.
Raj ChandranAbbott Laboratories, Abbott Park, Illinois, USA.
Jaime A MarinoAbbott Laboratories, Abbott Park, Illinois, USA.
Beth McQuistonAbbott Laboratories, Abbott Park, Illinois, USA.
Hongwei ZhangAbbott Point of Care, Ottawa, Ontario, Canada.
Krista L CaudleU.S. Army Medical Materiel Development Activity (USAMMDA), Warfighter Brain Health Project Management Office (WBH PMO), Fort Detrick, Maryland, USA.
Kevin K W WangProgram for Neurotrauma, Neuroproteomics & Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, Florida, USA.
Ava M PuccioDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
John K YueDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Sabrina R TaylorBrain and Spinal Injury Center, University of California, San Francisco, San Francisco, California, USA.
Amy MarkowitzBrain and Spinal Injury Center, University of California, San Francisco, San Francisco, California, USA.
Geoffrey T ManleyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abbott Fund · USNeurological Surgery · USUniversity of California, San Diego · USUniversity of California, San Francisco · USAbbott (Canada) · CAPenn Presbyterian Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) may aid in the evaluation of traumatic brain injury (TBI). The objective of this analysis was to compare GFAP and UCH-L1 values measured using a handheld device compared with a core laboratory platform. We analyzed plasma samples from patients with TBI and healthy controls enrolled in the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) cohort study. GFAP and UCH-L1 were measured twice in each subject using prototype assays, first with the Abbott i-STAT™ handheld device, and second with the Abbott ARCHITECT

Indexed as

assaybiomarkersglial fibrillary acidic proteintraumatic brain injuryubiquitin carboxyl-terminal hydrolase L1

Identifiers

PMID33937911
PMCPMC8086519
OpenAlexW3142622822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.