Evidence map›Paper›PMID 33937860›Full record

ArticleRadiology. Artificial intelligence2021

CT-less Direct Correction of Attenuation and Scatter in the Image Space Using Deep Learning for Whole-Body FDG PET: Potential Benefits and Pitfalls.

Jaewon Yang, Jae Ho Sohn, Spencer C Behr, Grant T Gullberg, Youngho Seo

Open access · greenAbstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Large axial field of view PET/CT - Not just a longer PET gantry.Zeitschrift fur medizinische Physik · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. CT-free attenuation and Monte-Carlo based scatter correction-guided quantitativeEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Context-Aware Transformer GAN for Direct Generation of Attenuation and Scatter Corrected PET Data.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  16. Differential privacy preserved federated transfer learning for multi-institutionalEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  17. Article
  18. Article
  19. Ethical Considerations for Artificial Intelligence in Medical Imaging: Deployment and Governance.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jaewon YangDepartment of Radiology and Biomedical Imaging (J.Y., J.H.S., S.C.B., G.TG., Y.S.) and Physics Research Laboratory (J.Y., G.T.G., Y.S.), University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94143-0946.ORCID 0000-0001-7637-0436
Jae Ho SohnDepartment of Radiology and Biomedical Imaging (J.Y., J.H.S., S.C.B., G.TG., Y.S.) and Physics Research Laboratory (J.Y., G.T.G., Y.S.), University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94143-0946.ORCID 0000-0002-6733-7551
Spencer C BehrDepartment of Radiology and Biomedical Imaging (J.Y., J.H.S., S.C.B., G.TG., Y.S.) and Physics Research Laboratory (J.Y., G.T.G., Y.S.), University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94143-0946.ORCID 0000-0001-9400-0543
Grant T GullbergDepartment of Radiology and Biomedical Imaging (J.Y., J.H.S., S.C.B., G.TG., Y.S.) and Physics Research Laboratory (J.Y., G.T.G., Y.S.), University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94143-0946.
Youngho SeoDepartment of Radiology and Biomedical Imaging (J.Y., J.H.S., S.C.B., G.TG., Y.S.) and Physics Research Laboratory (J.Y., G.T.G., Y.S.), University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94143-0946.
University of California System · US

Funding

Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
Energy-independent single photon molecular imaging technologyR01EB026331 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CUI, YONGGANG, SEO, YOUNGHO · 2018 to 2022
$2.6M
Dynamic cardiac SPECTR01HL135490 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GULLBERG, GRANT T, SEO, YOUNGHO · 2017 to 2020
$2.4M
NHLBI NIH HHS R01 HL135490NIBIB NIH HHS R01 EB026331NIBIB NIH HHS T32 EB001631
6 · The paper itself

Abstract

purposeTo demonstrate the feasibility of CT-less attenuation and scatter correction (ASC) in the image space using deep learning for whole-body PET, with a focus on the potential benefits and pitfalls. MATERIALS AND

methodsIn this retrospective study, 110 whole-body fluorodeoxyglucose (FDG) PET/CT studies acquired in 107 patients (mean age ± standard deviation, 58 years ± 18; age range, 11-92 years; 72 females) from February 2016 through January 2018 were randomly collected. A total of 37.3% (41 of 110) of the studies showed metastases, with diverse FDG PET findings throughout the whole body. A U-Net-based network was developed for directly transforming noncorrected PET (PET

resultsThe normalized root mean square error (0.21 ± 0.05 [mean SUV ± standard deviation]), mean peak signal-to-noise ratio (36.3 ± 3.0), mean structural similarity index (0.98 ± 0.01), and voxelwise correlation (97.62%) of PET

conclusionDeep learning-based direct ASC at whole-body PET is feasible and potentially can be used to overcome the current limitations of CT-based approaches, benefiting patients who are sensitive to radiation from CT.

Identifiers

PMID33937860
PMCPMC8043359
OpenAlexW3107814158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.