Evidence map›Paper›PMID 33937850›Full record

ArticleRadiology. Artificial intelligence2021

A Multisite Study of a Breast Density Deep Learning Model for Full-Field Digital Mammography and Synthetic Mammography.

Thomas P Matthews, Sadanand Singh, Brent Mombourquette, Jason Su, Meet P Shah, Stefano Pedemonte, Aaron Long, David Maffit, Jenny Gurney, Rodrigo Morales Hoil and 5 more

Abstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Thomas P MatthewsWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0002-9365-6812
Sadanand SinghWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Brent MombourquetteWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0002-1793-0197
Jason SuWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0001-5987-1108
Meet P ShahWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Stefano PedemonteWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Aaron LongWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
David MaffitWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Jenny GurneyWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0001-8988-7522
Rodrigo Morales HoilWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0002-0573-8587
Nikita GhareWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).ORCID 0000-0002-2315-0576
Douglas SmithWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Stephen M MooreWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Susan C MarksWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).
Richard L WahlWhiterabbit AI, Inc, 3930 Freedom Circle, Suite 101, Santa Clara, CA 95054 (T.P.M., S.S., B.M., J.S., M.P.S., S.P., A.L., R.M.H., N.G., D.S.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.M., J.G., S.M.M., R.L.W.); and Peninsula Diagnostic Imaging, San Mateo, Calif (S.C.M.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop a Breast Imaging Reporting and Data System (BI-RADS) breast density deep learning (DL) model in a multisite setting for synthetic two-dimensional mammographic (SM) images derived from digital breast tomosynthesis examinations by using full-field digital mammographic (FFDM) images and limited SM data. MATERIALS AND

methodsA DL model was trained to predict BI-RADS breast density by using FFDM images acquired from 2008 to 2017 (site 1: 57 492 patients, 187 627 examinations, 750 752 images) for this retrospective study. The FFDM model was evaluated by using SM datasets from two institutions (site 1: 3842 patients, 3866 examinations, 14 472 images, acquired from 2016 to 2017; site 2: 7557 patients, 16 283 examinations, 63 973 images, 2015 to 2019). Each of the three datasets were then split into training, validation, and test. Adaptation methods were investigated to improve performance on the SM datasets, and the effect of dataset size on each adaptation method was considered. Statistical significance was assessed by using CIs, which were estimated by bootstrapping.

resultsWithout adaptation, the model demonstrated substantial agreement with the original reporting radiologists for all three datasets (site 1 FFDM: linearly weighted Cohen κ [κ

conclusionA BI-RADS breast density DL model demonstrated strong performance on FFDM and SM images from two institutions without training on SM images and improved by using few SM images.

Identifiers

PMID33937850
PMCPMC8082294

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.