ArticleEuropean oral research2021
The antibacterial effects of vitamin D3 against mutans streptococci: an in vitro study.
Article in European oral research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Differential modulation of gentamicin antibacterial activity by vitamin B12 and vitamin D3 against Gram-positive and Gram-negative bacteria: anAnnals of medicine · 2026Article
- Impact of Vitamin D Supplementation on Hospitalizations for Infection: Results of the D-Health Trial Revisited.Nutrients · 2026Article
- Article
- Vitamin D3 potentiates antimicrobial and antibiofilm activities of streptomycin and thymoquinone against Pseudomonas aeruginosa.World journal of microbiology & biotechnology · 2025Article
- The Antimicrobial Activity of Combination of Vitamin D3 and Omega-3 against Pathogenic Microorganisms.Combinatorial chemistry & high throughput screening · 2025Article
- Article
- Antibacterial activity of microwave synthesized hydroxyapatite against cariogenic bacteria: A preliminary study.The Saudi dental journal · 2024Article
- Cholecalciferol Exhibits no Antibacterial Effect onRecent advances in anti-infective drug discovery · 2024Article
- The antimicrobial effect of different vitamin D compounds onJournal of oral microbiology · 2024Article
- Antibacterial effectiveness of different zinc salts onThe Saudi dental journal · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aims to evaluate the antimicrobial effects of the cholecalciferol vitamin D3 against Streptococcus sobrinus (Strep. sobrinus) and Streptococcus mutans (Strep. mutans) bacteria in vitro that is considered the main causative bacteria in dental caries development. MATERIALS AND
methodsThe antimicrobial effects of vitamin D3 were evaluated against Strep. sobrinus and Strep mutans using the agar disc diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of vitamin D3 were determined using a microdilution method following the guidelines by the Clinical Laboratory Standards Institute (CLSI). Scanning electron microscope (SEM) was used to evaluate the morphological changes of bacterial cells following exposure to vitamin D3.
resultsStrep. sobrinus was more sensitive to vitamin D3 compared to Strep. mutans bacteria. The MIC values of vitamin D3 against Strep. sobrinus and Strep. mutans were 60 μg/ mL and 250 μg/mL respectively whereas the MBC values were 120 μg/mL and 500 μg/mL, respectively. Moreover, significant changes in the bacterial morphology were observed in treated bacterial cells with vitamin D3 as compared to the untreated control bacteria using SEM.
conclusionThese findings suggested that vitamin D3 has excellent antimicrobial effects against Strep. sobrinus and Strep. mutans and may be considered as a promising compound in the prevention of dental caries in the future. Further research is recommended to elucidate the mechanism of vitamin D3 on these bacteria.
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