ArticleOTA international : the open access journal of orthopaedic trauma2019
Bone marrow aspirate concentrate with cancellous allograft versus iliac crest bone graft in the treatment of long bone nonunions.
Article in OTA international : the open access journal of orthopaedic trauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic effect of autologous bone grafting with adjuvant bone morphogenetic protein on long bone nonunion: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Modern Approaches and Emerging Biological Therapies to Treat Fracture Nonunion.Pharmaceutics · 2025Review
- Olecranon stress fracture treated with headless compression screws and bone marrow aspirate concentrate augmentation: a case report and systematic review of the literature.JSES reviews, reports, and techniques · 2025Review
- Regional Gene Therapy for Bone Tissue Engineering: A Current Concepts Review.Bioengineering (Basel, Switzerland) · 2025Review
- Femoral Neck Fracture Non-Union: Treatment with Bone Marrow Concentrate, Demineralized Bone Matrix, and Morselized Allograft and Angular Stable Fixation. Report of 2 Cases.Journal of orthopaedic case reports · 2024Article
- Analysis of risk factors and development of a nomogram-based prediction model for defective bony non-union.Heliyon · 2024Article
- Contemporary Review: Autograft Bone Use in Foot and Ankle Surgery.Foot & ankle orthopaedics · 2023Review
- Intraoperative Creation of Tissue-Engineered Grafts with Minimally Manipulated Cells: New Concept of Bone Tissue Engineering In Situ.Bioengineering (Basel, Switzerland) · 2022Review
- Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist.ACS applied materials & interfaces · 2022Article
- Current Modalities for Fracture Healing Enhancement.Tissue engineering and regenerative medicine · 2022Review
- Calcaneal reconstruction using a femoral head allograft and biologic adjuncts: A case report.SAGE open medical case reports · 2022Article
- Epidemiology, Clinical Assessments, and Current Treatments of Nonunions.Current osteoporosis reports · 2020Review
- The top three unanswered questions in the management of open fractures.OTA international : the open access journal of orthopaedic trauma · 2020Article
- Research advances in bioactive bone graft materials and bone marrow enrichment techniques for bone defect treatment.Cell transplantationReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to compare bone marrow aspirate concentrate (BMAC) with cancellous allograft to iliac crest bone graft (ICBG) in the treatment of long bone nonunions.
designRetrospective cohort study.
settingA single level I trauma center. PATIENTS: 26 patients with long bone diaphyseal or metaphyseal nonunions with defects >2 mm and treated with open repair and BMAC, compared to 25 patients with long bone diaphyseal or metaphyseal nonunions with defects >2 mm and treated with open repair and ICBG.
interventionOpen repair of long bone nonunion using either autologous ICBG or BMAC with cancellous allograft.
main outcome measureNonunion healing, radiographically measured by the modified Radiographic Union Score for Tibia (mRUST) score. Secondary outcomes included risk factors associated with failed repair.
resultsThe union rates for the BMAC and ICBG cohorts were 75% and 78%, respectively (
conclusionIn this study, we found no significant difference in union rate for long bone nonunions treated with ICBG or BMAC with allograft. BMAC and allograft led to 75% successful healing in this series. Given the heterogeneity of the control group and loss to follow-up, further prospective investigation should be conducted to more rigorously compare BMAC to ICBG for nonunion treatment. LEVEL OF EVIDENCE: III, retrospective cohort.
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