Evidence map›Paper›PMID 33937581›Full record

ArticleCurrent opinion in endocrine and metabolic research2021

Sleep and the Testis.

Nora A O'Byrne, Fiona Yuen, Warda Niaz, Peter Y Liu

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Current opinion in endocrine and metabolic research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02256865 (Hormonal Mechanisms of Sleep Restriction), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02256865 early_phase1completednot on this map

Hormonal Mechanisms of Sleep Restriction

TypeinterventionalSponsorLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterRan2014 to 2023Enrolled40ConditionsInsulin ResistanceArmsKetoconazole, Hydrocortisone, Testosterone, Placebo for ketoconazole, Placebo for hydrocortisone
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Role of sleep in asthenospermia induced by di (2-ethyl-hexyl) phthalate.Environmental science and pollution research international · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Sleep and Circadian Regulation of Cortisol: A Short Review.Current opinion in endocrine and metabolic research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nora A O'ByrneThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA.
Fiona YuenThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA.
Warda NiazThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA.
Peter Y LiuThe Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA.
UCLA Medical Center · USUniversity of California, Los Angeles · US

Funding

Mentorship in the Endocrinology of SleepK24HL138632 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI LIU, PETER YIWEN · 2018 to 2022
$598k
NHLBI NIH HHS K24 HL138632
6 · The paper itself

Abstract

Disordered sleep impairs neurocognitive performance, and is now recognized to cause metabolic ill-health. This review assesses the nascent relationship between insufficient, misaligned, and disrupted sleep with andrological health. High-quality cohort studies show a reduced sperm count in men with sleep disturbances. Well-designed interventional studies show a reduction in testosterone with sleep restriction. Studies of long-term shift workers show no effect of misaligned sleep on mean testosterone concentrations. Men with obstructive sleep apnea (OSA) and more severe hypoxemia have lower testosterone levels, although it is unknown if this relationship is entirely explained by concomitant obesity, or is reversible. Nevertheless, erectile dysfunction, which is common in men with OSA, is clinically improved when OSA is properly treated. Few studies manipulating sleep have been performed in older men, in whom the accumulation of sleep disturbances over decades of life may contribute to age-related illnesses. Improving sleep could ameliorate the development of these disorders.

Indexed as

AndrogenCircadianFertilitySleepSleep Disordered Breathing

Identifiers

PMID33937581
PMCPMC8087280
OpenAlexW3136614483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.