Evidence map›Paper›PMID 33937445›Full record

ArticleNeurobiology of stress2021

Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of I

Sebastian Luca D'Addario, Matteo Di Segni, Ada Ledonne, Rosamaria Piscitelli, Lucy Babicola, Alessandro Martini, Elena Spoleti, Camilla Mancini, Donald Ielpo, Francesca R D'Amato and 7 more

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Sebastian Luca D'AddarioDept. of Psychology and Center "Daniel Bovet", Sapienza University, Rome, Italy.
Matteo Di SegniIRCCS Fondazione Santa Lucia, Roma, Italy.
Ada LedonneIRCCS Fondazione Santa Lucia, Roma, Italy.
Rosamaria PiscitelliIRCCS Fondazione Santa Lucia, Roma, Italy.
Lucy BabicolaDept. of Psychology and Center "Daniel Bovet", Sapienza University, Rome, Italy.
Alessandro MartiniIRCCS Fondazione Santa Lucia, Roma, Italy.
Elena SpoletiDepartment of Physiology and Pharmacology, Sapienza University, Rome, 00185, Italy.
Camilla ManciniUniversity of Camerino School of Pharmaceutical Sciences and Health Products, Camerino, Italy.
Donald IelpoDept. of Psychology and Center "Daniel Bovet", Sapienza University, Rome, Italy.
Francesca R D'AmatoBiochemistry and Cell Biology Institute, National Research Council, Via E Ramarini 32, 00015, Monterotondo Scalo, Roma, Italy.
Diego AndolinaDept. of Psychology and Center "Daniel Bovet", Sapienza University, Rome, Italy.
Davide RagozzinoIRCCS Fondazione Santa Lucia, Roma, Italy.
Nicola B MercuriIRCCS Fondazione Santa Lucia, Roma, Italy.
Carlo CifaniUniversity of Camerino School of Pharmaceutical Sciences and Health Products, Camerino, Italy.
Massimiliano RenziDepartment of Physiology and Pharmacology, Sapienza University, Rome, 00185, Italy.
Ezia GuatteoIRCCS Fondazione Santa Lucia, Roma, Italy.
Rossella VenturaDept. of Psychology and Center "Daniel Bovet", Sapienza University, Rome, Italy.
Fondazione Santa Lucia · ITParthenope University of Naples · ITSapienza University of Rome · ITUniversità di Camerino · ITNational Research Council · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to aversive events during sensitive developmental periods can affect the preferential coping strategy adopted by individuals later in life, leading to either stress-related psychiatric disorders, including depression, or to well-adaptation to future adversity and sources of stress, a behavior phenotype termed "resilience". We have previously shown that interfering with the development of mother-pups bond with the Repeated Cross Fostering (RCF) stress protocol can induce resilience to depression-like phenotype in adult C57BL/6J female mice. Here, we used patch-clamp recording in midbrain slice combined with both

Indexed as

Early stressIh currentIn vivo pharmacologyResilienceVTA

Identifiers

PMID33937445
PMCPMC8079665
OpenAlexW3156089745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.