Evidence map›Paper›PMID 33937434›Full record

ArticleOpen forum infectious diseases2021

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.

Síle F Molloy, Brad Ross, Cecilia Kanyama, Sayoki Mfinanga, Sokoine Lesikari, Robert S Heyderman, Newton Kalata, Jayne Ellis, Charles Kouanfack, Duncan Chanda and 15 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Neurological Sequelae After Paediatric Cryptococcal Meningitis.Journal of fungi (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Ophthalmic manifestations ofInternational journal of ophthalmology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 11 countries.

Síle F MolloyCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
Brad RossCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
Cecilia KanyamaUNC Project, Kamuzu Central Hospital, Lilongwe, Malawi.
Sayoki MfinangaNational Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
Sokoine LesikariNational Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
Robert S HeydermanUniversity College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-4573-449X
Newton KalataMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Jayne EllisMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.ORCID https://orcid.org/0000-0002-7009-9144
Charles KouanfackHȏpital Central Yaoundé/Site ANRS Cameroun, Yaoundé, Cameroon.
Duncan ChandaInstitute for Medical Research and Training, University Teaching Hospital, Lusaka, Zambia.
Elvis TemfackDouala General Hospital, Douala, Cameroon.ORCID https://orcid.org/0000-0001-8189-6555
Shabir LakhiUniversity Teaching Hospital, Lusaka, Zambia.
Anand MoodleyDepartment of Neurology, University of the Free State, Bloemfontein, South Africa.
Adrienne K ChanDignitas International, Zomba Central Hospital, Zomba, Malawi.
Joep J van OosterhoutPartners in Hope, LilongweMalawi.
Yacouba MapoureDouala General Hospital, Douala, Cameroon.
Peter MwabaDepartment of Internal Medicine and Directorate of Research and Post Graduate Studies, Lusaka Apex Medical University, Lusaka, Zambia.
David G LallooLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Duolao WangLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Olivier LortholaryInstitut Pasteur, Molecular Mycology Unit, Centre National de la Recherche Scientifique, Paris, France.
Shabbar JaffarLiverpool School of Tropical Medicine, Liverpool, United Kingdom.
Mina C HosseinipourUNC Project, Kamuzu Central Hospital, Lilongwe, Malawi.
Angela LoyseCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
Thomas S HarrisonCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
Tihana BicanicCentre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.ORCID https://orcid.org/0000-0002-2676-838X
Liverpool School of Tropical Medicine · GBSt. George's University · GDUniversity of Douala · CMUniversity of Liverpool · GBUniversity Teaching Hospital · ZMCentral Hospital of Yaoundé · CMDélégation Paris 5 · FRKamuzu Central Hospital · MWLusaka Apex Medical University · ZMNational Institute for Medical Research · TZPartners In Health · USSt George's, University of London · GBSunnybrook Health Science Centre · CAUniversity College Hospital · GBUniversity of North Carolina at Chapel Hill · USUniversity of the Free State · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH

Indexed as

cryptococcal meningitisfungal burdenHIVraised intracranial pressurevisual loss

Identifiers

PMID33937434
PMCPMC8078267
OpenAlexW3128451289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.