Evidence map›Paper›PMID 33937432›Full record

ArticleComputing in cardiology2020

Effect of Myocardial Fiber Direction on Epicardial Activation Patterns.

Lindsay C Rupp, Wilson W Good, Jake A Bergquist, Brian Zenger, Karli Gillette, Gernot Plank, Rob S MacLeod

Open access · bronzeAbstract read
In one paragraph

Article in Computing in cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lindsay C RuppScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Wilson W GoodScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Jake A BergquistScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Brian ZengerScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
Karli GilletteInstitute of Biophysics, Medical University of Graz, Graz, Austria.
Gernot PlankInstitute of Biophysics, Medical University of Graz, Graz, Austria.
Rob S MacLeodScientific Computing and Imaging Institute, University of Utah, SLC, UT, USA.
University of Utah · USMedical University of Graz · AT

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI MACLEOD, ROB S. · 2012 to 2019
$9.7M
Center for Integrative Biomedical Computing Legacy TransitionR24GM136986 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2020 to 2022
$1.6M
Integration of Uncertainty Quantification with SCIRun Bioelectric Field Simulation PipelineU24EB029012 · NIBIB · UNIVERSITY OF UTAH · PI MACLEOD, ROB S. · 2019 to 2021
$1.1M
Novel Characterization and Detection Techniques for Acute Myocardial IschemiaF30HL149327 · NHLBI · UNIVERSITY OF UTAH · PI ZENGER, BRIAN · 2020 to 2022
$117k
NHLBI NIH HHS F30 HL149327NIBIB NIH HHS U24 EB029012NIGMS NIH HHS P41 GM103545NIGMS NIH HHS R24 GM136986
6 · The paper itself

Abstract

Fiber structure governs the spread of excitation in the heart, however, little is known about the effects of physiological variability in the fiber orientation on epicardial activation. To investigate these effects, we used computer simulation to compare ventricular activation sequences initiated from stimulus sites at regularly spaced depths within the myocardium under varying rule-based fiber ranges. We compared the effects using four characteristics of epicardial breakthrough (BKT): location, area, shape (calculated via the axis ratio of a fitted ellipse), and orientation. Our results showed changes in the BKT characteristics as pacing depth increased, e.g., the area increased, the shape became more circular, and the orientation rotated counterclockwise, regardless of the fiber orientation. Furthermore, the maximal differences in epicardial activation from a single pacing site for location, area, axis ratio, and orientation were 1.2 mm, 74 mm

Identifiers

PMID33937432
PMCPMC8084599
OpenAlexW3118849307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.