Evidence map›Paper›PMID 33937354›Full record

ReviewFrontiers in cardiovascular medicine2021

Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis.

Giulia Elena Mandoli, Flavio D'Ascenzi, Giulia Vinco, Giovanni Benfari, Fabrizio Ricci, Marta Focardi, Luna Cavigli, Maria Concetta Pastore, Nicolò Sisti, Oreste De Vivo and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Cardio-Vascular Extracellular Matrix: The Unmet Enigma.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Nanomedicine for Diagnosis and Treatment of Cardiac Fibrosis.International journal of nanomedicine · 2025
    Review
  8. Editorial: Pre-interventional cardiac imaging.Frontiers in cardiovascular medicine · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Radiology of fibrosis. Part I: Thoracic organs.Journal of translational medicine · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Giulia Elena MandoliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Flavio D'AscenziDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Giulia VincoSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Giovanni BenfariSection of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Fabrizio RicciDepartment of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, "G.d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Marta FocardiDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Luna CavigliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Maria Concetta PastoreDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Nicolò SistiDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Oreste De VivoDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Ciro SantoroDepartment of Advanced Biomedical Science, Federico II University Hospital Naples, Naples, Italy.
Sergio MondilloDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
Matteo CameliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy.
University of Siena · ITUniversity of Verona · ITFederico II University Hospital · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yield and prognostic value of speckle tracking echocardiography, late gadolinium enhancement and parametric mapping modules by cardiac magnetic resonance and cardiac computed tomography have been validated against tissue samples and tested in broad patient populations, overall providing relevant clinical information to the cardiologist. This review describes the patterns of left ventricular and left atrial fibrosis, and their characterization by advanced echocardiography, cardiac magnetic resonance and cardiac computed tomography, allowing for clinical applications in sudden cardiac death and management of atrial fibrillation.

Indexed as

cardiac magnetic resonanceechocardiographyfibrosismyocardial strainspeckle tracking

Identifiers

PMID33937354
PMCPMC8081830
OpenAlexW3153887113

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.