Evidence map›Paper›PMID 33937259›Full record

ArticleFrontiers in cell and developmental biology2021

Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in

Lisa Frankenreiter, Bernd M Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C Nagel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lisa FrankenreiterDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
Bernd M GahrDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
Hannes SchmidDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
Mirjam ZimmermannDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
Sebastian DeichselDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
Philipp HoffmeisterDepartment of Internal Medicine 1, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.
Aleksandra TurkiewiczInstitute of Biochemistry, Justus-Liebig University of Giessen, Giessen, Germany.
Tilman BorggrefeInstitute of Biochemistry, Justus-Liebig University of Giessen, Giessen, Germany.
Franz OswaldDepartment of Internal Medicine 1, Center for Internal Medicine, University Medical Center Ulm, Ulm, Germany.
Anja C NagelDepartment of General Genetics (190g), Institute of Biology (190), University of Hohenheim, Stuttgart, Germany.
University of Hohenheim · DEUniversität Ulm · DEUniversity of Giessen · DE

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
NIH HHS P40 OD018537
6 · The paper itself

Abstract

The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors within the DNA-binding domain. Earlier we found that a phospho-mimetic mutation of the

Indexed as

DrosophilahematopoiesisNotch signalingphosphorylationSuppressor of Hairless

Identifiers

PMID33937259
PMCPMC8079769
OpenAlexW3153473677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.