ArticleFrontiers in cell and developmental biology2021
Melatonin Alleviates the Suppressive Effect of Hypoxanthine on Oocyte Nuclear Maturation and Restores Meiosis via the Melatonin Receptor 1 (MT1)-Mediated Pathway.
Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Melatonin in ovarian function and dysfunction: Molecular mechanisms and therapeutic potential.Journal of ovarian research · 2026Review
- Stage-dependent DNA damage and mitochondrial dysfunction under simulated microgravity constrain oocyte maturation and are mitigated by melatonin.Cell communication and signaling : CCS · 2026Article
- A Follicle Size Window of Competence for In Vitro Embryo Production in High-Producing Dairy Cows: Evidence from OPU-IVP Performance and Follicular Fluid Profiling.Animals : an open access journal from MDPI · 2026Article
- Reactive Oxygen Species in Embryo Development: Sources, Impacts, and Implications for In Vitro Culture Systems.Life (Basel, Switzerland) · 2026Review
- Whole genome resequencing reveals genetic diversity, population structure, and selection signatures in local duck breeds.BMC genomics · 2025Article
- The role of gut microbiota-gonadal axis in ovary activation of Asian honey bee (Apis cerana) queens.NPJ biofilms and microbiomes · 2025Article
- Beneficial effects of melatonin on canine oocyte nuclear maturation via reduction of oxidative stress.Reproduction (Cambridge, England) · 2025Article
- Article
- Melatonin decreases excessive polyspermy for single oocyte in pigs through the MT2 receptor.Scientific reports · 2024Article
- Melatonin Improves Turbot Oocyte Meiotic Maturation and Antioxidant Capacity, Inhibits Apoptosis-Related Genes mRNAs In Vitro.Antioxidants (Basel, Switzerland) · 2023Article
- Importance of Antioxidant Supplementation during In Vitro Maturation of Mammalian Oocytes.Veterinary sciences · 2022Review
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore the meiosis process. We conducted
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.