Evidence map›Paper›PMID 33937226›Full record

ArticleFrontiers in cell and developmental biology2021

Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and

Meera Manchanda, Emma Leishman, Kishan Sangani, Ali Alamri, Heather B Bradshaw

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  6. CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  7. Review
  8. Article
  9. A journey from molecule to physiology andFrontiers in pharmacology · 2023
    Review
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  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meera ManchandaBradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.
Emma LeishmanBradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.
Kishan SanganiBradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.
Ali AlamriBradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.
Heather B BradshawBradshaw Laboratory of Lipid Neuroscience, Indiana University Bloomington, Bloomington, IN, United States.
Indiana University Bloomington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocannabinoids (eCBs) and transient receptor potential (TRP) channels are associated with thermoregulation; however, there are many gaps in the understanding of how these signaling systems work together in responding to changes in temperature. TRPV1, a calcium-permeable ion channel, is activated by capsaicin, elevated temperature, the eCB Anandamide, and over 15 additional endogenous lipids. There is also evidence for signaling crosstalk between TRPV1 and the eCB receptor, CB

Indexed as

2-AGanandamideendocannabinoidlipidomicsthermoregulationTRPV1

Identifiers

PMID33937226
PMCPMC8085603
OpenAlexW3153402275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.