Evidence map›Paper›PMID 33937103›Full record

ArticleFrontiers in cellular and infection microbiology2021

Human Cytomegalovirus Genome Diversity in Longitudinally Collected Breast Milk Samples.

Jasper Götting, Katrin Lazar, Nicolás M Suárez, Lars Steinbrück, Tabea Rabe, Rangmar Goelz, Thomas F Schulz, Andrew J Davison, Klaus Hamprecht, Tina Ganzenmueller

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023
    Review
  6. Article
  7. [Effect of breastfeeding on immune function in infants with human cytomegalovirus infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jasper GöttingInstitute of Virology, Hannover Medical School, Hannover, Germany.
Katrin LazarInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany.
Nicolás M SuárezMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Lars SteinbrückInstitute of Virology, Hannover Medical School, Hannover, Germany.
Tabea RabeInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany.
Rangmar GoelzDepartment of Neonatology, University Children's Hospital, Tuebingen, Germany.
Thomas F SchulzInstitute of Virology, Hannover Medical School, Hannover, Germany.
Andrew J DavisonMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Klaus HamprechtInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany.
Tina GanzenmuellerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany.
Medizinische Hochschule Hannover · DEMRC University of Glasgow Centre for Virus Research · GBUniversity Children's Hospital Tübingen · DE

Funding

Medical Research Council MC_UU_12014/3
6 · The paper itself

Abstract

Reactivation and shedding of human cytomegalovirus (HCMV) in breast milk during lactation is highly frequent in HCMV-seropositive mothers. This represents a key transmission route for postnatal HCMV infection and can lead to severe disease in preterm neonates. Little is known about HCMV strain composition or longitudinal intrahost viral population dynamics in breast milk from immunocompetent women. We performed HCMV-specific target enrichment and high-throughput sequencing of 38 breast milk samples obtained in Germany between days 10 and 60 postpartum from 15 mothers with HCMV DNA lactia, and assembled HCMV consensus sequences

Indexed as

CytomegalovirusCytomegalovirus InfectionsDNA, ViralFemaleGermanyHumansInfantInfant, NewbornMilk, HumanDNA, Viralbreast milkcytomegalovirusdiversitygenomesgenotypingimmunocompetentlactationstrains

Identifiers

PMID33937103
PMCPMC8085339
OpenAlexW3153843637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.