ArticleFrontiers in oncology2021
Comparison of Diffusion Kurtosis Imaging and Amide Proton Transfer Imaging in the Diagnosis and Risk Assessment of Prostate Cancer.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- MR-based techniques for imaging prostate cancer metabolism: current status and future perspectives.Abdominal radiology (New York) · 2026Review
- Multiparametric magnetic resonance imaging (MRI) integrating amide proton transfer-weighted (APTw) imaging, synthetic MRI, and multiplexed sensitivity encoding diffusion-weighted imaging (MUSE DWI) in the diagnosis and grading of prostate cancer.Quantitative imaging in medicine and surgery · 2026Article
- Possible Role of Diffusion-Weighted Imaging in Prediction of Prostate Cancer Grade Group Upgrading: Insights from Biopsy to Radical Prostatectomy.Medicina (Kaunas, Lithuania) · 2026Article
- Clinical MR Biomarkers.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Exploring the value of multiparametric quantitative magnetic resonance imaging in avoiding unnecessary biopsy in patients with PI-RADS 3-4.Abdominal radiology (New York) · 2025Article
- Combination of PI-RADS version 2.1 and amide proton transfer values for the detection of clinically significant prostate cancer.BMC cancer · 2025Article
- Diagnosis and risk stratification of PI-RADS v2.1 category 3-5 lesions using amide proton transfer imaging.World journal of urology · 2025Article
- Evaluation of functional magnetic resonance APT and DKI imaging for breast cancer.Cancer cell international · 2024Article
- Article
- Comparison of diagnostic performance between diffusion models parameters and mono-exponential apparent diffusion coefficient in patients with prostate cancer: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Review
- Amide proton transfer imaging has added value for predicting extraprostatic extension in prostate cancer patients.Frontiers in oncology · 2024Article
- CEST-MRI for body oncologic imaging: are we there yet?NMR in biomedicine · 2023Review
- Comparison and combination of amide proton transfer magnetic resonance imaging and the apparent diffusion coefficient in differentiating the grades of prostate cancer.Quantitative imaging in medicine and surgery · 2023Article
- APTw combined with mDixon-Quant imaging to distinguish the differentiation degree of cervical squamous carcinoma.Frontiers in oncology · 2023Article
- Emerging MR methods for improved diagnosis of prostate cancer by multiparametric MRI.Magma (New York, N.Y.) · 2022Review
- Combining Magnetic Resonance Diffusion-Weighted Imaging with Prostate-Specific Antigen to Differentiate Between Malignant and Benign Prostate Lesions.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Amide proton transfer weighted imaging combined with dynamic contrast-enhanced MRI in predicting lymphovascular space invasion and deep stromal invasion of IB1-IIA1 cervical cancer.Frontiers in oncology · 2022Article
- A Brief History and Future Prospects of CEST MRI in Clinical Non-Brain Tumor Imaging.International journal of molecular sciences · 2021Review
- Amide Proton Transfer Weighted and Intravoxel Incoherent Motion Imaging in Evaluation of Prognostic Factors for Rectal Adenocarcinoma.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to evaluate and compare the diagnostic value of DKI and APT in prostate cancer (PCa), and their correlation with Gleason Score (GS). MATERIALS AND
methodsDKI and APT imaging of 49 patients with PCa and 51 patients with benign prostatic hyperplasia (BPH) were collected and analyzed, respectively. According to the GS, the patients with PCa were divided into high-risk, intermediate-risk and low-risk groups. The mean kurtosis (MK), mean diffusion (MD) and magnetization transfer ratio asymmetry (MTRasym, 3.5 ppm) values among PCa, BPH, and different GS groups of PCa were compared and analyzed respectively. The diagnostic accuracy of each parameter was evaluated by using the receiver operating characteristic (ROC) curve. The correlation between each parameter and GS was analyzed by using Spearman's rank correlation.
resultsThe MK and MTRasym (3.5 ppm) values were significantly higher in PCa group than in BPH group, while the MD value was significantly lower than in BPH group. The differences of MK/MD/MTRasym (3.5 ppm) between any two of the low-risk, intermediate-risk, and high-risk groups were all statistically significant (p <0.05). The MK value showed the highest diagnostic accuracy in differentiating PCa and BPH, BPH and low-risk, low-risk and intermediate-risk, intermediate-risk and high-risk (AUC = 0.965, 0.882, 0.839, 0.836). The MK/MD/MTRasym (3.ppm) values showed good and moderate correlation with GS (
conclusionDKI and APT imaging are valuable in the diagnosis of PCa and demonstrate strong correlation with GS, which has great significance in the risk assessment of PCa.
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