ArticleQuantitative imaging in medicine and surgery2021
Simultaneous hepatic iron and fat quantification with dual-energy CT in a rabbit model of coexisting iron and fat.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Effect of radiation dose on quantification of the liver iron and fat fractions using dual-energy computed tomography and material decomposition.Quantitative imaging in medicine and surgery · 2025Article
- Added value of amide proton transfer-weighted magnetic resonance imaging to Prostate Imaging Reporting and Data System version 2.1 in differentiating clinically significant prostate cancer.Quantitative imaging in medicine and surgery · 2024Article
- Fat quantification in dual-layer detector spectral CT: How to handle iron overload, varying tube voltage and radiation dose Indices.PloS one · 2024Article
- Extracellular volume by dual-energy CT, hepatic reserve capacity scoring, CT volumetry, and transient elastography for estimating liver fibrosis.Scientific reports · 2023Article
- The evolution and current situation in the application of dual-energy computed tomography: a bibliometric study.Quantitative imaging in medicine and surgery · 2023Article
- Quantification of bone quality and distribution of the proximal humerus with dual-energy computed tomography.Quantitative imaging in medicine and surgery · 2023Article
- Utility of CT in detecting and monitoring subphrenic jujube pits: a retrospective cross-sectional study of clinical cases andQuantitative imaging in medicine and surgery · 2022Article
- Dual-source dual-energy computed tomography-derived quantitative parameters combined with machine learning for the differential diagnosis of benign and malignant thyroid nodules.Quantitative imaging in medicine and surgery · 2022Article
- Quantitative assessment of liver steatosis using ultrasound: dual-energy CT.Journal of medical ultrasonics (2001) · 2021Review
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver iron and fat are often co-deposited, synergistically aggravating the progression of chronic liver disease. Accurate determination of liver iron and fat content is helpful for patient management. To assess the accuracy of hepatic iron/fat decomposition using dual-energy computed tomography (DECT) for simultaneously quantifying hepatic iron and fat when both are present.
methodsSixty-eight New Zealand rabbits on a high-fat/cholesterol diet plus iron injections were used to establish a model of coexisting hepatic iron/fat. Abdominal imaging was performed using dual-source DECT. The iron and fat fractions (Iron-
resultsIron-
conclusionsOur DECT-based iron/fat decomposition algorithm accurately measured hepatic iron and fat when both were present in a rabbit model. Hepatic fat may be underestimated when there is massive iron overload.
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