ArticleQuantitative imaging in medicine and surgery2021
Quantitative assessment of structural and functional changes in temporal lobe epilepsy with hippocampal sclerosis.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.Communications medicine · 2025Article
- Brain-clinical signatures for vagus nerve stimulation response.CNS neuroscience & therapeutics · 2023Article
- Surface-based morphological patterns associated with neuropsychological performance, symptom severity, and treatment response in Parkinson's disease.Annals of translational medicine · 2022Article
- Metabolic phenotyping of hand automatisms in mesial temporal lobe epilepsy.EJNMMI research · 2022Article
- Preserved microstructural integrity of the corticospinal tract in patients with glioma-induced motor epilepsy: a study using mean apparent propagator magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2022Article
- Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects.International journal of molecular sciences · 2021Review
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
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Abstract
backgroundMagnetic resonance imaging (MRI) changes in hippocampal sclerosis (HS) could be subtle in a significant proportion of mesial temporal lobe epilepsy (mTLE) patients. In this study, we aimed to document the structural and functional changes in the hippocampus and amygdala seen in HS patients.
methodsQuantitative features of the hippocampus and amygdala were extracted from structural MRI data in 66 mTLE patients and 28 controls. Structural covariance analysis was undertaken using volumetric data from the amygdala and hippocampus. Functional connectivity (FC) measured using resting intracranial electroencephalography (EEG) was analyzed in 22 HS patients and 16 non-HS disease controls.
resultsHippocampal atrophy was present in both MRI-positive and MRI-negative HS groups (Mann-Whitney
conclusionsQuantitative structural changes, including hippocampal atrophy and temporal pole blurring, are present in both MRI-positive and MRI-negative HS patients, suggesting the potential usefulness of incorporating quantitative analyses into clinical practice. HS is characterized by increased intra-hippocampal EEG synchronization and decreased coupling between the hippocampus and amygdala.
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