Evidence map›Paper›PMID 33936958›Full record

ArticleQuantitative imaging in medicine and surgery2021

Longitudinal changes on liver proton density fat fraction differ between liver segments.

Jan Syväri, Daniela Junker, Lisa Patzelt, Katharina Kappo, Loubna Al Sadat, Sonia Erfanian, Marcus R Makowski, Hans Hauner, Dimitrios C Karampinos

Open access · diamondAbstract read
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Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jan SyväriDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Daniela JunkerDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Lisa PatzeltDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Katharina KappoInstitute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Loubna Al SadatInstitute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Sonia ErfanianInstitute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Marcus R MakowskiDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Hans HaunerInstitute for Nutritional Medicine, Else Kroener-Fresenius-Center of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Dimitrios C KarampinosDepartment of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany.
Technical University of Munich · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo study the spatial heterogeneity of liver fat fraction changes during a long-term lifestyle intervention study using magnetic resonance imaging (MRI).

methodsThirty-two subjects underwent two MRI-scans in a span of one year. A chemical shift encoding-based water-fat separation method was applied to measure liver proton density fat fraction (PDFF) maps. The PDFF changes in the two liver lobes and the Couinaud segments were compared with the mean liver PDFF change.

resultsThe slope of the relationship between mean liver PDFF changes and PDFF liver lobe changes was higher in the right compared to the left lobe (slope

conclusionsLarger PDFF changes in the right liver lobe were observed compared to PDFF changes in the left liver lobe (LLL) in subjects with both increasing and decreasing mean liver PDFF after one year. The results are in line with the existing literature reporting a heterogeneous spatial distribution of liver fat and highlight the need to spatially resolve liver fat fraction changes in longitudinal studies.

Indexed as

Dixon MRILifestyle intervention studyliver fat fraction spatial heterogeneityproton density fat fraction (PDFF)quantitative MRI

Identifiers

PMID33936958
PMCPMC8047351
OpenAlexW3135761106

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.