Evidence map›Paper›PMID 33936831›Full record

ArticleCase reports in urology2021

Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy.

Kamyar Ghabili, Nathan Paulson, Jamil S Syed, Cayce B Nawaf, Ghazal Khajir, Darryl T Martin, John Onofrey, Michael S Leapman, Angelique Levi, Jeffrey C Weinreb and 2 more

Abstract readCase Reports
In one paragraph

Article in Case reports in urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kamyar GhabiliDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
Nathan PaulsonDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Jamil S SyedDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
Cayce B NawafDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
Ghazal KhajirDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
Darryl T MartinDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
John OnofreyDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Michael S LeapmanDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.
Angelique LeviDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Jeffrey C WeinrebDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Peter A HumphreyDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Preston C SprenkleDepartment of Urology, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-0502-9294

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The utility of serial Decipher biopsy scores in a true active surveillance population is still unknown. In a man on active surveillance for low-risk prostate cancer, a doubling of the Decipher biopsy score within genomic low-risk category from first to the second biopsy related to biopsy reclassification to Gleason grade group 4 on the third biopsy. However, the final pathology at radical prostatectomy showed Gleason grade group 2 with an organ-confined disease. This case suggests that the genomic risk category of Decipher biopsy scores during active surveillance may be more informative than either the interval genomic score change or the biopsy Gleason grade group.

Identifiers

PMID33936831
PMCPMC8054861

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.