Evidence map›Paper›PMID 33936772›Full record

ArticleActa crystallographica. Section E, Crystallographic communications2021

Maleate salts of bedaquiline.

Matthias Zeller, Susan Bogdanowich-Knipp, Pamela Smith, Dale K Purcell, Mercy Okezue, Daniel T Smith, Stephen R Byrn, Kari L Clase

Open access · goldAbstract read
In one paragraph

Article in Acta crystallographica. Section E, Crystallographic communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Comparison of pharmacokinetics and bioavailability of bedaquiline fumarate, benzoate and maleate in dogs.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthias ZellerDepartment of Chemistry, Purdue University, 560 Oval Dr., W. Lafayette, IN 47907-2084, USA.ORCID https://orcid.org/0000-0002-3305-852X
Susan Bogdanowich-KnippRavine Pharmaceuticals LLC, 3425 DuBois St., West Lafayette, IN 47906, USA.
Pamela SmithLeading with Smart Science LLC, 5315 Shootingstar Ln, West Lafayette, IN 47906, USA.ORCID https://orcid.org/0000-0002-8405-5409
Dale K PurcellChemical Microscopy LLC, 1281 Win Hentschel Blvd., West Lafayette, IN 47906, USA.
Mercy OkezueBiotechnology Innovation and Regulatory Science Center, Lilly Hall of Life Sciences, 915 State Street, Purdue University, West Lafayette, IN 47906, USA.ORCID https://orcid.org/0000-0002-3157-5021
Daniel T SmithIndustrial and Physical Pharmacy, Purdue University, 575 Stadium Mall, West Lafayette, IN 47906, USA.
Stephen R ByrnImproved Pharma LLC, 1281 Win Hentschel Blvd. Suite 1565, West Lafayette, IN 47906, USA.
Kari L ClaseBiotechnology Innovation and Regulatory Science Center, Lilly Hall of Life Sciences, 915 State Street, Purdue University, West Lafayette, IN 47906, USA.ORCID https://orcid.org/0000-0003-2749-6440
Purdue University West Lafayette · USState Street (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). It is marketed in the US as its fumarate salt, but only a few salts of bedaquiline have been structurally described so far. We present here five crystal structures of bedaquilinium maleate {systematic name: [4-(6-bromo-2-meth-oxy-quinolin-3-yl)-3-hy-droxy-3-(naphthalen-1-yl)-4-phenyl-but-yl]di-methyl-aza-nium 3-carb-oxy-prop-2-enoate}, C

Indexed as

bedaquilinecrystal structuredesolvationdrug-resistant tuberculosisisomorphous organic salts

Identifiers

PMID33936772
PMCPMC8025853
OpenAlexW3144581627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.