Evidence map›Paper›PMID 33936568›Full record

ArticleJournal of extracellular vesicles2021

Nanoalgosomes: Introducing extracellular vesicles produced by microalgae.

Giorgia Adamo, David Fierli, Daniele P Romancino, Sabrina Picciotto, Maria E Barone, Anita Aranyos, Darja Božič, Svenja Morsbach, Samuele Raccosta, Christopher Stanly and 25 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Review
  2. Article
  3. Natural Product-Derived Vesicles in Nanotherapeutics.Journal of extracellular vesicles · 2026
    Review
  4. Article
  5. TopicalPharmaceutics · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Anti-fibrotic effect ofFrontiers in bioengineering and biotechnology · 2026
    Article
  19. Review
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Giorgia AdamoInstitute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.
David FierliCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo Ireland.
Daniele P RomancinoInstitute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.
Sabrina PicciottoInstitute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.
Maria E BaroneCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo Ireland.
Anita AranyosCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo Ireland.
Darja BožičUniversity of Ljubljana (UL) Ljubljana Slovene.
Svenja MorsbachMax Planck Institute for Polymer Research (MPIP) Mainz Germany.
Samuele RaccostaInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Christopher StanlyInstitute of Biosciences and BioResources (IBBR) - National Research Council of Italy (CNR) Naples Italy.
Carolina PaganiniDepartment of Chemistry and Applied Biosciences ETH Zurich Zurich Switzerland.
Meiyu GaiMax Planck Institute for Polymer Research (MPIP) Mainz Germany.
Antonella CusimanoInstitute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.
Vincenzo MartoranaInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Rosina NotoInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Rita CarrottaInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Fabio LibrizziInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Loredana RandazzoInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Rachel ParkesCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo Ireland.
Umberto Capasso PalmieroDepartment of Chemistry and Applied Biosciences ETH Zurich Zurich Switzerland.
Estella RaoInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Angela PaternaInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.
Pamela SantonicolaInstitute of Biosciences and BioResources (IBBR) - National Research Council of Italy (CNR) Naples Italy.
Ales IgličUniversity of Ljubljana (UL) Ljubljana Slovene.
Laura CorcueraZabala Innovation Consulting Pamplona Spain.
Annamaria KisslingerInstitute of Experimental Endocrinology and Oncology (IEOS) - National Research Council of Italy (CNR) Naples Italy.
Elia Di SchiaviInstitute of Biosciences and BioResources (IBBR) - National Research Council of Italy (CNR) Naples Italy.
Giovanna L LiguoriInstitute of Genetics and Biophysics (IGB) - National Research Council of Italy (CNR) Naples Italy.
Katharina LandfesterMax Planck Institute for Polymer Research (MPIP) Mainz Germany.
Veronika Kralj-IgličUniversity of Ljubljana (UL) Ljubljana Slovene.
Paolo ArosioDepartment of Chemistry and Applied Biosciences ETH Zurich Zurich Switzerland.
Gabriella PocsfalviInstitute of Biosciences and BioResources (IBBR) - National Research Council of Italy (CNR) Naples Italy.
Nicolas TouzetCentre for Environmental Research Innovation and Sustainability Institute of Technology Sligo Sligo Ireland.
Mauro MannoInstitute of Biophysics (IBF) - National Research Council of Italy (CNR) Palermo Italy.ORCID 0000-0001-9843-0428
Antonella BongiovanniInstitute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR) Palermo Italy.ORCID 0000-0002-0307-4043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular, inter-organismal and cross kingdom communication via extracellular vesicles (EVs) is intensively studied in basic science with high expectation for a large variety of bio-technological applications. EVs intrinsically possess many attributes of a drug delivery vehicle. Beyond the implications for basic cell biology, academic and industrial interests in EVs have increased in the last few years. Microalgae constitute sustainable and renewable sources of bioactive compounds with a range of sectoral applications, including the formulation of health supplements, cosmetic products and food ingredients. Here we describe a newly discovered subtype of EVs derived from microalgae, which we named nanoalgosomes. We isolated these extracellular nano-objects from cultures of microalgal strains, including the marine photosynthetic chlorophyte

Indexed as

Drug Delivery SystemsExtracellular VesiclesMicroalgaeUltracentrifugationbiogenic nano‐delivery systemEV‐based therapeuticsextracellular vesicles of non‐mammalian organismsmicroalgaemicroalgal extracellular vesiclesnanoalgosomes

Identifiers

PMID33936568
PMCPMC8077145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.