Evidence map›Paper›PMID 33936412›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2020

Leverage Real-world Longitudinal Data in Large Clinical Research Networks for Alzheimer's Disease and Related Dementia (ADRD).

Rui Duan, Zhaoyi Chen, Jiayi Tong, Chongliang Luo, Tianchen Lyu, Cui Tao, Demetrius Maraganore, Jiang Bian, Yong Chen

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A Deep Subgrouping Framework for Precision Drug Repurposing via Emulating Clinical Trials on Real-world Patient Data.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. The OneFlorida Data Trust: a centralized, translational research data infrastructure of statewide scope.Journal of the American Medical Informatics Association : JAMIA · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui DuanDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Zhaoyi ChenDepartment of Epidemiology, College of Medicine & College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Jiayi TongDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
Chongliang LuoDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.
Tianchen LyuDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Cui TaoSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Demetrius MaraganoreDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.
Jiang BianDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.
Yong ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Dynamic learning for post-vaccine event prediction using temporal information in VAERSR01AI130460 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHEN, YONG, TAO, CUI · 2017 to 2021
$3.4M
The benefits and harms of lung cancer screening in FloridaR01CA246418 · NCI · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, GUO, YI · 2020 to 2023
$1.7M
A General Framework to Account for Outcome Reporting Bias in Systematic ReviewsR01LM012607 · NLM · UNIVERSITY OF PENNSYLVANIA · PI CHEN, YONG · 2017 to 2020
$1.4M
Systematic Analysis of Clinical Study Generalizability Assessment Methods with InformaticsR21AG061431 · NIA · FLORIDA STATE UNIVERSITY · PI BIAN, JIANG, HE, ZHE · 2019 to 2020
$793k
NCATS NIH HHS UL1 TR001427NCI NIH HHS R01 CA246418NIAID NIH HHS R01 AI130460NIA NIH HHS R21 AG061431NLM NIH HHS R01 LM012607
6 · The paper itself

Abstract

With vast amounts ofpatients' medical information, electronic health records (EHRs) are becoming one of the most important data sources in biomedical and health care research. Effectively integrating data from multiple clinical sites can help provide more generalized real-world evidence that is clinically meaningful. To analyze the clinical data from multiple sites, distributed algorithms are developed to protect patient privacy without sharing individual-level medical information. In this paper, we applied the One-shot Distributed Algorithm for Cox proportional hazard model (ODAC) to the longitudinal data from the OneFlorida Clinical Research Consortium to demonstrate the feasibility of implementing the distributed algorithms in large research networks. We studied the associations between the clinical risk factors and Alzheimer's disease and related dementia (ADRD) onsets to advance clinical research on our understanding of the complex risk factors of ADRD and ultimately improve the care of ADRD patients.

Indexed as

AlgorithmsAlzheimer DiseaseDementiaElectronic Health RecordsHumansProportional Hazards ModelsRisk Factors

Identifiers

PMID33936412
PMCPMC8075520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.