ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2020
Finding Causal Mechanistic Drug-Drug Interactions from Observational Data.
Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A comprehensive landscape of AI applications in broad-spectrum drug interaction prediction: a systematic review.Journal of cheminformatics · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Many adverse drug reactions (ADRs) are caused by drug-drug interactions (DDIs), meaning they arise from concurrent use of multiple medications. Detecting DDIs using observational data has at least three major challenges: (1) The number of potential DDIs is astronomical; (2) Associations between drugs and ADRs may not be causal due to observed or unobserved confounding; and (3) Frequently co-prescribed drug pairs that each independently cause an ADR do not necessarily causally interact, where causal interaction means that at least some patients would only experience the ADR if they take both drugs. We address (1) through data mining algorithms pre-filtering potential interactions, and (2) and (3) by fitting causal interaction models adjusting for observed confounders and conducting sensitivity analyses for unobserved confounding. We rank candidate DDIs robust to unobserved confounding more likely to be real. Our rigorous approach produces far fewer false positives than past applications that ignored (2) and (3).
Indexed as
Identifiers
33936409PMC8075465What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.