Evidence map›Paper›PMID 33936405›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2020

Diagnosability of Synthetic Retinal Fundus Images for Plus Disease Detection in Retinopathy of Prematurity.

Aaron S Coyner, Jimmy Chen, J Peter Campbell, Susan Ostmo, Praveer Singh, Jayashree Kalpathy-Cramer, Michael F Chiang

Open access · greenAbstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Computer vision - ECCV ... : ... European Conference on Computer Vision : proceedings. European Conference on Computer Vision · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Aaron S CoynerMedical Informatics & Clinical Epidemiology.
Jimmy ChenOphthalmology Oregon Health & Science University, Portland, OR, United States.
J Peter CampbellOphthalmology Oregon Health & Science University, Portland, OR, United States.
Susan OstmoOphthalmology Oregon Health & Science University, Portland, OR, United States.
Praveer SinghRadiology, MGH/Harvard Medical School, Charlestown, MA, United States.
Jayashree Kalpathy-CramerRadiology, MGH/Harvard Medical School, Charlestown, MA, United States.
Michael F ChiangMedical Informatics & Clinical Epidemiology.
Institute for Medical Informatics and Biostatistics · CH

Funding

TRAINING PROGRAM IN HEALTH INFORMATICST15LM007088 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAM R HERSH, Vishnu Mohan · 1992 to 2026
$23.4M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell · 1995 to 2026
$19.4M
Clinical and Genetic Analysis of Retinopathy of PrematurityR01EY019474 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAMPBELL, JOHN PETER · 2010 to 2020
$7.0M
Mentored Vision Clinician-Scientist Program at OHSUK12EY027720 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2018 to 2026
$2.2M
NEI NIH HHS K12 EY027720NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY019474NLM NIH HHS T15 LM007088
6 · The paper itself

Abstract

Advances in generative adversarial networks have allowed for engineering of highly-realistic images. Many studies have applied these techniques to medical images. However, evaluation of generated medical images often relies upon image quality and reconstruction metrics, and subjective evaluation by laypersons. This is acceptable for generation of images depicting everyday objects, but not for medical images, where there may be subtle features experts rely upon for diagnosis. We implemented the pix2pix generative adversarial network for retinal fundus image generation, and evaluated the ability of experts to identify generated images as such and to form accurate diagnoses of plus disease in retinopathy of prematurity. We found that, while experts could discern between real and generated images, the diagnoses between image sets were similar. By directly evaluating and confirming physicians' abilities to diagnose generated retinal fundus images, this work supports conclusions that generated images may be viable for dataset augmentation and physician training.

Indexed as

Fundus OculiHumansImage Processing, Computer-AssistedInfant, NewbornRetinal ArteryRetinal VeinRetinopathy of Prematurity

Identifiers

PMID33936405
PMCPMC8075515
OpenAlexW3157073783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.