Evidence map›Paper›PMID 33936091›Full record

ReviewFrontiers in immunology2021

Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem?

Amélie Bonaud, Julia P Lemos, Marion Espéli, Karl Balabanian

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Importance of B cells (Review).International journal of molecular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Amélie BonaudUniversité de Paris, Institut de Recherche Saint-Louis, EMiLy, INSERM U1160, Paris, France.
Julia P LemosUniversité de Paris, Institut de Recherche Saint-Louis, EMiLy, INSERM U1160, Paris, France.
Marion EspéliUniversité de Paris, Institut de Recherche Saint-Louis, EMiLy, INSERM U1160, Paris, France.
Karl BalabanianUniversité de Paris, Institut de Recherche Saint-Louis, EMiLy, INSERM U1160, Paris, France.
Hôpital Saint-Louis · FRInserm · FRInstitut de recherche Saint-LouisUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic cells reside. In this review, we discuss the bone marrow niches in mice that facilitate the survival, maintenance, and differentiation of cells of hematopoietic origin based on the recent literature. Our review places a special focus on the hematopoietic multipotent progenitors and on plasma cells, corresponding to the last stage of the B-cell lineage, that play a key role in the humoral memory response. We highlight the similarities between the microenvironments necessary for the establishment and the maintenance of these two immune cell subsets, and how the chemokine CXCL12/CXCR4 signaling axis contributes to these processes. Finally, we bring elements to address the following question: are multipotent progenitors and plasma cells neighbors or roommates within the bone marrow?

Indexed as

Cell DifferentiationLymphopoiesisAnimalsBiomarkersBone MarrowBone Marrow CellsCell CommunicationCellular MicroenvironmentHematopoietic Stem CellsMiceOsteoblastsPlasma CellsStem Cell NicheBiomarkersbone marrowCXCR4hematopoietic stem and progenitor cell nicheslymphoid lineagemultipotent progenitorsplasma cellsWHIM syndrome

Identifiers

PMID33936091
PMCPMC8083056
OpenAlexW3156505749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.