Evidence map›Paper›PMID 33936074›Full record

ArticleFrontiers in immunology2021

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake

Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M Woodruff, Edimara da Silva Reis, John D Lambris, Denise V Tambourgi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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  3. Complement System Inhibitory Drugs in a Zebrafish (International journal of molecular sciences · 2023
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  4. New Insights into Immunopathology Associated toInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Frontiers in immunology · 2022
    Article
  9. Investigations on the Changes of Serum Proteins in Rabbits afterEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Felipe Silva de FrançaImmunochemistry Laboratory, Instituto Butantan, São Paulo, Brazil.
Isadora Maria Villas-BoasImmunochemistry Laboratory, Instituto Butantan, São Paulo, Brazil.
Bruno CogliatiDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Trent M WoodruffNeuroinflammation Laboratory, School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.
Edimara da Silva ReisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
John D LambrisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Denise V TambourgiImmunochemistry Laboratory, Instituto Butantan, São Paulo, Brazil.
Instituto Butantan · BRUniversity of Pennsylvania · USUniversidade de São Paulo · BRUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement's contribution to the physiopathogenesis of

Indexed as

AnimalsBiomarkersChemokinesComplement ActivationComplement C5aDisease Models, AnimalHumansHydrolysisInflammationInflammation MediatorsMaleMiceModels, BiologicalNajaProtein BindingReceptor, Anaphylatoxin C5aBiomarkersC5AR1 protein, humanChemokinesComplement C5aInflammation MediatorsReceptor, Anaphylatoxin C5aSnake VenomsC5a-C5aR1complement inhibitorscomplement systemenvenomationNaja snake venom

Identifiers

PMID33936074
PMCPMC8082402
OpenAlexW3153675610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.