Evidence map›Paper›PMID 33936070›Full record

ArticleFrontiers in immunology2021

Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines

Marilena P Etna, Martina Severa, Valerio Licursi, Manuela Pardini, Melania Cruciani, Fabiana Rizzo, Elena Giacomini, Gianfranco Macchia, Orazio Palumbo, Raffaella Stallone and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Marilena P EtnaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Martina SeveraDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Valerio LicursiDepartment of Biology and Biotechnology, Sapienza University, Rome, Italy.
Manuela PardiniDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Melania CrucianiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Fabiana RizzoDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Elena GiacominiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Gianfranco MacchiaProteomics Core Facility, Istituto Superiore di Sanità, Rome, Italy.
Orazio PalumboDivision of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Raffaella StalloneDivision of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Massimo CarellaDivision of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Mark LivingstoneCytokine Signaling Unit, Inserm, Institut Pasteur, Paris, France.
Rodolfo NegriDepartment of Biology and Biotechnology, Sapienza University, Rome, Italy.
Sandra PellegriniCytokine Signaling Unit, Inserm, Institut Pasteur, Paris, France.
Eliana M CocciaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITCasa Sollievo della Sofferenza · ITInserm · FRSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In human primary dendritic cells (DC) rapamycin-an autophagy inducer and protein synthesis inhibitor-overcomes the autophagy block induced by

Indexed as

AutophagyCells, CulturedCytokinesDendritic CellsGene Expression ProfilingGlycogen Synthase Kinase 3 betaHumansMycobacterium tuberculosisPrimary Cell CultureSignal TransductionSirolimusTOR Serine-Threonine KinasesTuberculosisCytokinesGlycogen Synthase Kinase 3 betaGSK3B protein, humanMTOR protein, humanSirolimusTOR Serine-Threonine Kinasesautophagyhost-directed therapyIFNMycobacterium tuberculosisrapalogstranscriptometranslatometuberculosis

Identifiers

PMID33936070
PMCPMC8086600
OpenAlexW3154039764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.