Evidence map›Paper›PMID 33936029›Full record

ReviewFrontiers in immunology2021

Neutrophils: Need for Standardized Nomenclature.

Ellen McKenna, Aisling Ui Mhaonaigh, Richard Wubben, Amrita Dwivedi, Tim Hurley, Lynne A Kelly, Nigel J Stevenson, Mark A Little, Eleanor J Molloy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  12. Article
  13. The Disordered Region of ASXL1 Acts as an Auto-Regulator Through Condensation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ellen McKennaDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Aisling Ui MhaonaighTrinity Health Kidney Centre, TTMI, Trinity College, Dublin, Ireland.
Richard WubbenViral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland.
Amrita DwivediTrinity Health Kidney Centre, TTMI, Trinity College, Dublin, Ireland.
Tim HurleyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Lynne A KellyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Nigel J StevensonViral Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin, Ireland.
Mark A LittleTrinity Health Kidney Centre, TTMI, Trinity College, Dublin, Ireland.
Eleanor J MolloyDiscipline of Paediatrics, Trinity College, The University of Dublin, Dublin, Ireland.
Trinity College Dublin · IESt. James's Hospital · IETallaght University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, polymorphonuclear neutrophils (PMN), granulocytic myeloid derived suppressor cells (G-MDSC), low density neutrophils (LDN) and tumor associated neutrophils (TANS). This lack of standardized nomenclature for neutrophils suggest that biologically distinct populations of neutrophils exist, particularly in disease, when in fact these may simply be a manifestation of the plasticity of the neutrophil as opposed to unique populations. In this review, we profile the surface markers and granule expression of each stage of granulopoiesis to offer insight into how each stage of maturity may be identified. We also highlight the remarkable surface marker expression profiles between the supposed neutrophil populations.

Indexed as

Myeloid-Derived Suppressor CellsNeutrophilsSecretory VesiclesGene Expression RegulationHumansTerminology as Topicgranulopoiesislow density neutrophilsneutrophil granulesneutrophilsnomenclature

Identifiers

PMID33936029
PMCPMC8081893
OpenAlexW3153415150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.