Evidence map›Paper›PMID 33935961›Full record

ArticleFrontiers in endocrinology2020

microRNA-214-3p Suppresses Ankylosing Spondylitis Fibroblast Osteogenesis

Lixiang Ding, Yukun Yin, Yu Hou, Haoran Jiang, Ji Zhang, Zhong Dai, Genai Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Mechanical Strain-Programmed SDC1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
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  6. Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets.International journal of biological sciences · 2025
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lixiang DingDepartment of Spine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yukun YinDepartment of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu HouDepartment of Spine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Haoran JiangDepartment of Spine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Ji ZhangDepartment of Spine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Zhong DaiDepartment of General Medicine, Huanxing Cancer Hospital, Beijing, China.
Genai ZhangDepartment of Spine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Beijing Shijitan Hospital · CNCancer Hospital of Huanxing Chaoyang District Beijing · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent investigations suggest microRNAs (miRs) exert functions in fibroblast osteogenesis in ankylosing spondylitis (AS), an inflammatory rheumatic disease. But the mechanism of miR-214-3p in osteogenic differentiation in AS is not clearly understood yet. In this study, fibroblasts were obtained from the capsular ligament of patients with AS and femoral neck fracture and cultured for osteogenic induction and identified. The roles of miR-214-3p and bone morphogenic protein 2 (BMP2) in AS fibroblast osteogenesis were assessed

Indexed as

AdultAlkaline PhosphataseBone Morphogenetic Protein 2Bone Morphogenetic ProteinsCell DifferentiationCells, CulturedDown-RegulationFemaleFibroblastsHumansMaleMicroRNAsOsteogenesisSignal TransductionSpondylitis, AnkylosingTransforming Growth Factor alphaAlkaline PhosphataseBMP2 protein, humanBone Morphogenetic Protein 2Bone Morphogenetic ProteinsMicroRNAsMirn214 microRNA, mouseTransforming Growth Factor alphaankylosing spondylitisBMP–TGFβ signaling pathwaybone morphogenic protein 2microRNA-214-3posteogenic differentiation

Identifiers

PMID33935961
PMCPMC8082363
OpenAlexW3156526731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.