ArticleFrontiers in neurology2021
Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 18 citations in OpenAlex.
- Characteristics of brain glucose metabolism in Parkinson's disease patients with freezing of gait: a study based onBMC neurology · 2025Article
- Cholinergic System Changes in Dopa-Unresponsive Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Usefulness of Olfactory Bulb Measurement in 3D-FIESTA in Differentiating Parkinson Disease from Atypical Parkinsonism.AJNR. American journal of neuroradiology · 2024Article
- Article
- Knowledge mapping of freezing of gait in Parkinson's disease: a bibliometric analysis.Frontiers in neuroscience · 2024Article
- Abnormal functional connectivity density involvement in freezing of gait and its application for subtyping Parkinson's disease.Brain imaging and behavior · 2023Article
- Review
- Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder.Frontiers in neuroscience · 2023Article
- Impaired structural and reserved functional topological organizations of brain networks in Parkinson's disease with freezing of gait.Quantitative imaging in medicine and surgery · 2023Article
- Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Structural Brain Network Abnormalities in Parkinson's Disease With Freezing of Gait.Frontiers in aging neuroscience · 2022Article
- Combining Neuroimaging and Omics Datasets for Disease Classification Using Graph Neural Networks.Frontiers in neuroscience · 2022Article
- Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Epileptogenic Zone Localization in Refractory Epilepsy by FDG-PET: The Comparison of SPM and SPM-CAT With Different Parameter Settings.Frontiers in neurology · 2021Article
- Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freezing of gait (FOG) has devastating consequences for patients with Parkinson's disease (PD), but the underlying pathophysiological mechanism is unclear. This was investigated in the present study by integrated structural and functional connectivity analyses of PD patients with or without FOG (PD FOG+ and PD FOG-, respectively) and healthy control (HC) subjects. We performed resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging of 24 PD FOG+ patients, 37 PD FOG- patients, and 24 HCs. Tract-based spatial statistics was applied to identify white matter (WM) abnormalities across the whole brain. Fractional anisotropy (FA) and mean diffusivity (MD) of abnormal WM areas were compared among groups, and correlations between these parameters and clinical severity as determined by FOG Questionnaire (FOGQ) score were analyzed. Voxel-mirrored homotopic connectivity (VMHC) was calculated to identify brain regions with abnormal interhemispheric connectivity. Structural and functional measures were integrated by calculating correlations between VMHC and FOGQ score and between FA, MD, and VMHC. The results showed that PD FOG+ and PD FOG- patients had decreased FA in the corpus callosum (CC), cingulum (hippocampus), and superior longitudinal fasciculus and increased MD in the CC, internal capsule, corona radiata, superior longitudinal fasciculus, and thalamus. PD FOG+ patients had more WM abnormalities than PD FOG- patients. FA and MD differed significantly among the splenium, body, and genu of the CC in all three groups (
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