Evidence map›Paper›PMID 33935807›Full record

ReviewFrontiers in physiology2021

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health.

Christine M Latham, Camille R Brightwell, Alexander R Keeble, Brooke D Munson, Nicholas T Thomas, Alyaa M Zagzoog, Christopher S Fry, Jean L Fry

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05505253 (Alfacalcidol Supplementation on Levator Ani Muscle Strength of Menopausal Pelvic Organ Prolapse Patients), which is not on this map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05505253 phase3completednot on this map

Alfacalcidol Supplementation on Levator Ani Muscle Strength of Menopausal Pelvic Organ Prolapse Patients

TypeinterventionalSponsorUniversitas PadjadjaranRan2020 to 2021Enrolled48ConditionsPelvic Organ ProlapseArmsAlfacalcidol 0.0005 MG, Placebo
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 138 citations in OpenAlex.

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  17. [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christine M LathamDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Camille R BrightwellDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Alexander R KeebleDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Brooke D MunsonDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Nicholas T ThomasDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Alyaa M ZagzoogDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Christopher S FryDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
Jean L FryDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States.
University of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated following injury, particularly in central nuclei and SCs in animal models of muscle injury. Mechanistic studies provide some insight into the possible role of vitamin D activity in injured muscle.

Indexed as

25(OH)Dcalcitriolreactive oxygen speciessatellite cellsskeletal muscle injuryskeletal muscle regenerationvitamin Dvitamin D receptor

Identifiers

PMID33935807
PMCPMC8079814
OpenAlexW3155423631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.