Evidence map›Paper›PMID 33935679›Full record

ArticleFrontiers in synaptic neuroscience2021

Naturalistic Spike Trains Drive State-Dependent Homeostatic Plasticity in Superficial Layers of Visual Cortex.

Varun Chokshi, Bryce D Grier, Andrew Dykman, Crystal L Lantz, Ernst Niebur, Elizabeth M Quinlan, Hey-Kyoung Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in synaptic neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Varun ChokshiThe Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.
Bryce D GrierThe Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.
Andrew DykmanThe Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.
Crystal L LantzDepartment of Biology, University of Maryland, College Park, MD, United States.
Ernst NieburThe Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.
Elizabeth M QuinlanDepartment of Biology, University of Maryland, College Park, MD, United States.
Hey-Kyoung LeeThe Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, United States.
Johns Hopkins University · USUniversity of Maryland, College Park · USAllen Institute for Brain Science · USDiscovery Institute · US

Funding

Global Synpatic Plasticity Mechanisms in Visual CortexR01EY014882 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Hey-Kyoung Lee · 2004 to 2026
$7.9M
Synaptic Plasticity in Young versus Aged Visual CortexR01EY016431 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Elizabeth Mary Quinlan · 2006 to 2026
$5.9M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Reversible activation on critical plasticity in visual cortexR01EY025922 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI KIRKWOOD, ALFREDO, MURASE, SACHIKO · 2015 to 2024
$3.6M
CRCNS:Proto-object based perceptual organization in three dimensionsR01EY027544 · NEI · JOHNS HOPKINS UNIVERSITY · PI ETIENNE-CUMMINGS, RALPH, NIEBUR, ERNST · 2016 to 2018
$1.1M
NEI NIH HHS R01 EY014882NEI NIH HHS R01 EY016431NEI NIH HHS R01 EY025922NEI NIH HHS R01 EY027544NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

The history of neural activity determines the synaptic plasticity mechanisms employed in the brain. Previous studies report a rapid reduction in the strength of excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons of the primary visual cortex (V1) following two days of dark exposure and subsequent re-exposure to light. The abrupt increase in visually driven activity is predicted to drive homeostatic plasticity, however, the parameters of neural activity that trigger these changes are unknown. To determine this, we first recorded spike trains

Indexed as

homeostatic plasticitymEPSCsmetaplasticityminiature excitatory postsynaptic currentsPoisson stimulationsynaptic depressionvisual experience

Identifiers

PMID33935679
PMCPMC8081846
OpenAlexW3153793717

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.