ArticleFrontiers in human neuroscience2021
Working Memory Training Effects on White Matter Integrity in Young and Older Adults.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effects of physical activity on visuospatial working memory in healthy individuals: A systematic review and meta-analysis.Frontiers in psychology · 2023Pooled it
- Adaptive working memory training does not produce transfer effects in cognition and neuroimaging.Translational psychiatry · 2022Trial
- Differential Transfer Effects Across Tasks in Younger and Older Adults Following Executive Function Training.Journal of cognitive enhancement : towards the integration of theory and practice · 2026Article
- Telomere Length, Brain Imaging-Derived Phenotypes, and Alzheimer's Disease: Mendelian Randomization Analysis.Molecular neurobiology · 2025Article
- Microstructural differences in the cingulum and the inferior longitudinal fasciculus are associated with (extinction) learning.BMC psychology · 2024Article
- Premorbid brain structure influences risk of amyotrophic lateral sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy.Epilepsia open · 2023Article
- The role of brain white matter in depression resilience and response to sleep interventions.Brain communications · 2023Article
- Adaptive and maladaptive myelination in health and disease.Nature reviews. Neurology · 2022Review
- Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Foods (Basel, Switzerland) · 2022Article
- Tract-Based Spatial Statistics Analysis of Diffusion Tensor Imaging in Older Adults After the PICMOR Intervention Program: A Pilot Study.Frontiers in aging neuroscience · 2022Article
- Orientational changes of white matter fibers in Alzheimer's disease and amnestic mild cognitive impairment.Human brain mapping · 2021Article
- Plasticity After Hearing Rehabilitation in the Aging Brain.Trends in hearingArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWorking memory is essential for daily life skills like reading comprehension, reasoning, and problem-solving. Healthy aging of the brain goes along with working memory decline that can affect older people's independence in everyday life. Interventions in the form of cognitive training are a promising tool for delaying age-related working memory decline, yet the underlying structural plasticity of white matter is hardly studied.
methodsWe conducted a longitudinal diffusion tensor imaging study to investigate the effects of an intensive four-week adaptive working memory training on white matter integrity quantified by global and tract-wise mean diffusivity. We compared diffusivity measures of fiber tracts that are associated with working memory of 32 young and 20 older participants that were randomly assigned to a working memory training group or an active control group.
resultsThe behavioral analysis showed an increase in working memory performance after the four-week adaptive working memory training. The neuroanatomical analysis revealed a decrease in mean diffusivity in the working memory training group after the training intervention in the right inferior longitudinal fasciculus for the older adults. There was also a decrease in mean diffusivity in the working memory training group in the right superior longitudinal fasciculus for the older and young participants after the intervention.
conclusionThis study shows that older people can benefit from working memory training by improving their working memory performance that is also reflected in terms of improved white matter integrity in the superior longitudinal fasciculus and the inferior longitudinal fasciculus, where the first is an essential component of the frontoparietal network known to be essential in working memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.