Evidence map›Paper›PMID 33935648›Full record

ReviewFrontiers in molecular neuroscience2021

Visual Outcomes in Experimental Rodent Models of Blast-Mediated Traumatic Brain Injury.

Lucy P Evans, Ariel M Roghair, Noah J Gilkes, Alexander G Bassuk

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Blast injury: Impact to the cornea.Experimental eye research · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lucy P EvansDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Ariel M RoghairDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Noah J GilkesDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
Alexander G BassukDepartment of Pediatrics, University of Iowa, Iowa City, IA, United States.
University of Iowa · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
Genetic & immunologic etiology of chronic recurrent multifocal osteomyelitis-CRMOR01AR059703 · NIAMS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G, FERGUSON, POLLY J · 2010 to 2019
$3.5M
Exploring Novel Epilepsy PathwaysR01NS098590 · NINDS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G · 2016 to 2020
$2.8M
Dissection and manipulation of inflammatory pathways underlying post-traumatic visual outcomesF30EY031245 · NEI · UNIVERSITY OF IOWA · PI EVANS, LUCY PRATT · 2020 to 2021
$81k
NEI NIH HHS F30 EY031245NIAMS NIH HHS R01 AR059703NIGMS NIH HHS T32 GM007337NINDS NIH HHS R01 NS098590
6 · The paper itself

Abstract

Blast-mediated traumatic brain injuries (bTBI) cause long-lasting physical, cognitive, and psychological disorders, including persistent visual impairment. No known therapies are currently utilized in humans to lessen the lingering and often serious symptoms. With TBI mortality decreasing due to advancements in medical and protective technologies, there is growing interest in understanding the pathology of visual dysfunction after bTBI. However, this is complicated by numerous variables, e.g., injury location, severity, and head and body shielding. This review summarizes the visual outcomes observed by various, current experimental rodent models of bTBI, and identifies data showing that bTBI activates inflammatory and apoptotic signaling leading to visual dysfunction. Pharmacologic treatments blocking inflammation and cell death pathways reported to alleviate visual deficits in post-bTBI animal models are discussed. Notably, techniques for assessing bTBI outcomes across exposure paradigms differed widely, so we urge future studies to compare multiple models of blast injury, to allow data to be directly compared.

Indexed as

blastbTBIretinarodenttraumatic brain injuryvisual function

Identifiers

PMID33935648
PMCPMC8081965
OpenAlexW3156967271

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.