Evidence map›Paper›PMID 33935641›Full record

SynthesisFrontiers in neuroscience2021

The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Xiaohong Zhang, Guangyi Bao, Debiao Liu, Yu Yang, Xuezhi Li, Gaomei Cai, Yan Liu, Yili Wu

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  15. Article
  16. Mitochondrial One-Carbon Metabolism and Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiaohong ZhangCollege of Marine Life Sciences, Ocean University of China, Qingdao, China.
Guangyi BaoShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Debiao LiuShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Yu YangShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Xuezhi LiShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Gaomei CaiDepartment of Neurology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
Yan LiuShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Yili WuShandong Key Laboratory of Behavioral Medicine, School of Mental Health, Jining Medical University, Jining, China.
Jining Medical University · CNAffiliated Hospital of Jining Medical University · CNOcean University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD. To investigate the role of folate deficiency/possible deficiency in the risk of AD and the benefical effect of sufficient folate intake on the prevention of AD, a systematic review and meta-analysis were performed. The Web of Science, PubMed, CENTRAL, EBSCO, CNKI, CQVIP, and Wanfang databases were searched. The analysis of cross-sectional studies showed that the standardized mean difference (SMD) was -0.60 (95% confidence interval (CI): -0.65, -0.55), indicating that plasma/serum folate level is lower in AD patients than that in controls. Moreover, the combined odds ratio (OR) of case-control studies was 0.96 (95% CI: 0.93, 0.99), while the combined ORs were 0.86 (95% CI: 0.46, 1.26) and 1.94 (95% CI: 1.02, 2.86) in populations with normal levels of folate (≥13.5 nmol/L) and folate deficiency/possible deficiency (<13.5 nmol/L), respectively. In addition, the risk ratio (RR) of the cohort studies was 1.88 (95% CI: 1.20, 2.57) in populations with folate deficiency/possible deficiency. Furthermore, when the intake of folate was equal to or higher than the recommended daily allowance, the combined RR and hazard ratio (HR) were 0.44 (95% CI: 0.18, 0.71) and 0.76 (95% CI: 0.52, 0.99), respectively. These results indicate that folate deficiency/possible deficiency increases the risk for AD, while sufficient intake of folate is a protective factor against AD.

Indexed as

Alzheimer's diseasefolate deficiencyfolate levelmeta-analaysissufficient folate intake

Identifiers

PMID33935641
PMCPMC8079632
OpenAlexW3155733596

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.