Evidence map›Paper›PMID 33935635›Full record

ReviewFrontiers in neuroscience2021

Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock.

Daisuke Ono, Ken-Ichi Honma, Sato Honma

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026
    Article
  6. Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. One seasonal clock fits all?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daisuke OnoDepartment of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Ken-Ichi HonmaResearch and Education Center for Brain Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Sato HonmaResearch and Education Center for Brain Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hokkaido University · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Individual SCN cells exhibit intrinsic oscillations, and their circadian period and robustness are different cell by cell in the absence of cellular coupling, indicating that cellular coupling is important for coherent circadian rhythms in the SCN. Several neuropeptides such as arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are expressed in the SCN, where these neuropeptides function as synchronizers and are important for entrainment to environmental light and for determining the circadian period. These neuropeptides are also related to developmental changes of the circadian system of the SCN. Transcription factors are required for the formation of neuropeptide-related neuronal networks. Although VIP is critical for synchrony of circadian rhythms in the neonatal SCN, it is not required for synchrony in the embryonic SCN. During postnatal development, the clock genes

Indexed as

AVPcircadian rhythmentrainmentneuronal couplingsuprachiasmatic nucleussynchronizationVIP

Identifiers

PMID33935635
PMCPMC8081951
OpenAlexW3155555709

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.