ArticleCrystal growth & design2020
Polymer-Assisted Aripiprazole-Adipic Acid Cocrystals Produced by Hot Melt Extrusion Techniques.
Article in Crystal growth & design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Integrative green synthesis and molecular simulation of ibrutinib cocrystals for enhanced biopharmaceutical performance and in vivo pharmacokinetics.International journal of pharmaceutics: X · 2025Article
- Current Perspectives on Development and Applications of Cocrystals in the Pharmaceutical and Medical Domain.Cureus · 2024Review
- Nanogels Based on N,N-Dimethylacrylamide and β-Cyclodextrin Triacrylate for Enhanced Solubility and Therapeutic Efficacy of Aripiprazole.Gels (Basel, Switzerland) · 2024Article
- HPMCAS-Based Amorphous Solid Dispersions in Clinic: A Review on Manufacturing Techniques (Hot Melt Extrusion and Spray Drying), Marketed Products and Patents.Materials (Basel, Switzerland) · 2023Review
- In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability.AAPS PharmSciTech · 2023Article
- Hard Gelatin Capsules Containing Hot Melt Extruded Solid Crystal Suspension of Carbamazepine for improving dissolution: Preparation andJournal of drug delivery science and technology · 2023Article
- Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs.Pharmaceutical research · 2023Article
- Design and optimization of ciprofloxacin hydrochloride biodegradable 3D printed ocular inserts: Full factorial design and in-vitro and ex-vivo evaluations: Part II.International journal of pharmaceutics · 2023Article
- Creation of Hydrochlorothiazide Pharmaceutical Cocrystals Via Hot-Melt Extrusion for Enhanced Solubility and Permeability.AAPS PharmSciTech · 2022Article
- Influence of PlasdoneAAPS PharmSciTech · 2021Article
- Multicomponent crystalline solid forms of aripiprazole produced via hot melt extrusion techniques: An exploratory study.Journal of drug delivery science and technology · 2021Article
- 3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling.International journal of pharmaceutics · 2021Review
- Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals.Pharmaceutics · 2021Article
- Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021Review
- Pharmaceutical Co-Crystals, Salts, and Co-Amorphous Systems: A Novel Opportunity of Hot Melt Extrusion.Journal of drug delivery science and technology · 2021Article
- Recent Advances in Pharmaceutical Cocrystals: From Bench to Market.Frontiers in pharmacology · 2021Review
- Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing.AAPS PharmSciTech · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Pharmaceutical cocrystals are a promising strategy to increase the solubility and dissolution rate of poorly soluble drugs. However, their manufacturing process requires a large quantity of solvents. The present study aimed to produce cocrystals by a solvent-free hot melt extrusion (HME) method to improve their solubility and dissolution rate. Aripiprazole (ARP) and adipic acid (ADP) were used as a weakly basic drug and acidic coformer, respectively. The processability of a plain ARP-ADP physical mixture (PM) compared with a PM with 5% Soluplus® (SOL) was investigated. Incorporating 5% SOL into the ARP-ADP blend reduced the processing torque and improved processability. The effects of temperature and screw speed on the formation of cocrystals were studied, and cocrystals were characterized by differential scanning calorimetry (DSC), fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, powder X-ray diffraction (PXRD), scanning electron microscopy, and hot-stage microscopy. FTIR spectra revealed noncovalent interaction between ARP and ADP, which was confirmed by NMR spectra. Similarly, PXRD data exhibited characteristic peaks confirming the formation of new crystalline material. Further, the results indicated that cocrystals demonstrated higher dissolution rates and improved compressibility, as well as enhanced flow characteristics compared with pure ARP, suggesting its suitability in the development of solid dosage forms.
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Registered trials
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