Evidence map›Paper›PMID 33935416›Full record

ArticleVeterinary world2021

Anticancer activity of milk fat rich in conjugated linoleic acid against Ehrlich ascites carcinoma cells in female Swiss albino mice.

Abdelrahman M Abd El-Gawad, Diea G Abo El-Hassan, Ahmed M Aboul-Enein, Sherein S Abdelgayed, Salwa A Aly, Gamal Esmat, Amr A Mostafa, Mohamed H Bakr, Rida A Ali, Mahmoud A Ayoub

Open access · goldAbstract read
In one paragraph

Article in Veterinary world, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Conjugated Linoleic Acid in Cancer Therapy.Current drug delivery · 2025
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Abdelrahman M Abd El-GawadDepartment of Animal Production, Faculty of Agriculture, Cairo University, Giza, Egypt.
Diea G Abo El-HassanDepartment of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Ahmed M Aboul-EneinDepartment of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt.
Sherein S AbdelgayedDepartment of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Salwa A AlyDepartment of Food Hygiene, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Gamal EsmatDepartment of Hepatogastroenterology and Infectious Diseases, Faculty of Medicine, Cairo University, Giza, Egypt.
Amr A MostafaDepartment of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt.
Mohamed H BakrDepartment of Animal Production, Faculty of Agriculture, Cairo University, Giza, Egypt.
Rida A AliDepartment of Animal Production, Faculty of Agriculture, Cairo University, Giza, Egypt.
Mahmoud A AyoubDepartment of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Giza, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimThe major conjugated linoleic acid (CLA) isomers have anticancer effect, especially breast cancer cells, inhibits cell growth and induces cell death. Also, CLA has several health benefits MATERIALS AND

methodsOne hundred and fifty adult female mice were equally divided into five groups. Groups (1-2) were normal controls, and Groups (3-5) were tumor transplanted mice (TTM) inoculated intraperitoneally with EAC cells (2×10

resultsFor CLA treated TTM, significant decrease in tumor weight, ascetic volume, viable Ehrlich cells accompanied with increase in life span were observed. Hematological and biochemical profiles reverted to more or less normal levels and histopathology showed minimal effects.

conclusionThe present study proved the safety and anticancer efficiency of milk fat CLA and provides a scientific basis for its medicinal use as anticancer attributable to the additive or synergistic effects of its isomers.

Indexed as

anticancer activityconjugated linoleic acidEhrlich ascites carcinoma % increase in life spanmean survival timetumor transplanted mice

Identifiers

PMID33935416
PMCPMC8076465
OpenAlexW3136895223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.