ArticleProceedings of the National Academy of Sciences of the United States of America1988
Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
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Who cites it
74 citing papers in PubMed.
- The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer's disease.Archives of toxicology · 2025Review
- Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Synaptic memory and CaMKII.Physiological reviews · 2023Review
- Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.Science signaling · 2023Article
- Synaptic memory survives molecular turnover.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Glucocorticoid-Regulated Kinase CAMKIγ in the Central Amygdala Controls Anxiety-like Behavior in Mice.International journal of molecular sciences · 2022Article
- Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2.PLoS computational biology · 2022Article
- Synaptic memory requires CaMKII.eLife · 2021Article
- Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention.Communications biology · 2021Article
- Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling.Cell reports · 2021Article
- Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway.Neurotoxicity research · 2020Article
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- What does LTP tell us about the roles of CaMKII and PKMζ in memory?Molecular brain · 2018Review
- In memoriam: John Lisman - commentaries on CaMKII as a memory molecule.Molecular brain · 2018Article
- Active dendrites regulate the spatiotemporal spread of signaling microdomains.PLoS computational biology · 2018Article
- Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Criteria for identifying the molecular basis of the engram (CaMKII, PKMzeta).Molecular brain · 2017Review
- Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory.Annual review of neuroscience · 2017Review
- AMPA Receptor Trafficking in Natural and Pathological Aging.Frontiers in molecular neuroscience · 2017Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability necessary to encode long-term memory, and that a group of kinase molecules, such as that contained within the postsynaptic density, could form a device capable of storing graded information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.