Evidence map›Paper›PMID 33935071›Full record

ArticleJournal of Alzheimer's disease : JAD2021

Longitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults.

Samantha L Gardener, Michael Weinborn, Hamid R Sohrabi, James D Doecke, Pierrick Bourgeat, Stephanie R Rainey-Smith, Kai-Kai Shen, Jurgen Fripp, Kevin Taddei, Paul Maruff and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Samantha L GardenerCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Michael WeinbornCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Hamid R SohrabiCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
James D DoeckeCSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australia.
Pierrick BourgeatCSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australia.
Stephanie R Rainey-SmithCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Kai-Kai ShenCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Jurgen FrippCSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australia.
Kevin TaddeiCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Paul MaruffCogState, Ltd., Melbourne, Victoria, Australia.
Olivier SalvadoCSIRO Health and Biosecurity/Australian eHealth Research Centre, Herston, Queensland, Australia.
Greg SavageARC Centre of Excellence in Cognition and its Disorders and Department of Psychology, Macquarie University, New South Wales, Australia.
David AmesNational Ageing Research Institute, Royal Melbourne Hospital, Melbourne, Australia.
Colin L MastersThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.
Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research & Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
AIBL Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research has identified a small subgroup of older adults that maintain a high level of cognitive functioning well into advanced age. Investigation of those with superior cognitive performance (SCP) for their age is important, as age-related decline has previously been thought to be inevitable.

objectivePreservation of cortical thickness and volume was evaluated in 76 older adults with SCP and 100 typical older adults (TOAs) assessed up to five times over six years.

methodsRegions of interest (ROIs) found to have been associated with super-aging status (a construct similar to SCP status) in previous literature were investigated, followed by a discovery phase analyses of additional regions. SCPs were aged 70 + at baseline, scoring at/above normative memory (CVLT-II) levels for demographically similar individuals aged 30-44 years old, and in the unimpaired range for all other cognitive domains over the course of the study.

resultsIn linear mixed models, following adjustment for multiple comparisons, there were no significant differences between rates of thinning or volume atrophy between SCPs and TOAs in previously identified ROIs, or the discovery phase analyses. With only amyloid-β negative individuals in the analyses, again there were no significant differences between SCPs and TOAs.

conclusionThe increased methodological rigor in classifying groups, together with the influence of cognitive reserve, are discussed as potential factors accounting for our findings as compared to the extant literature on those with superior cognitive performance for their age.

Indexed as

Brain Cortical ThicknessAgedAged, 80 and overAgingAtrophyCerebral CortexCognitionFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsOrgan Sizecerebral volume atrophyCognitive agingcortical thicknesscortical thinningolder adult superior cognitive performancesuper-aging

Identifiers

PMID33935071
PMCPMC8293653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.